Explore Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T28265
|
| Target Name |
Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5265
|
| Gene ID |
24648 (Rattus norvegicus), 280699 (Bos taurus), 480422 (Canis lupus familiaris), 5265 (Homo sapiens)
701361 (Macaca mulatta)
|
| Target Alternative Names |
A1A,A1AT,AAT,Alpha 1 Antitrypsin,Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Alpha-1-antitrypsin,PI,PI1,PRO2275,Pi,SERPINA1,Serpin A1,Serpina1,Spi1,alpha1AT,nNIF
|
| Uniprot Accession |
P17475,P34955,P01009
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Malignant neoplasm of bladder, IgA glomerulonephritis, Nephrotic syndrome with focal and segmental glomerular lesions, Diabetic Nephropathy, Contrast - Induced Nephropathy, Congenital occlusion of ureteropelvic junction, Calculus of kidney, Nephrotic syndrome, Acute pancreatitis, Juvenile arthritis, Urinary bladder urothelial carcinoma, Type 2 diabetes mellitus with diabetic nephropathy, protease
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSBTAG00000018843, ENSCAFG00845002999, ENSG00000197249, ENSMMUG00000020426
|
Pre-made viral vector of Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 cDNA Clones/ORF Plasmid
Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5265 | Pre-made Human SERPINA1/PI/A1A siRNA oligo Duplex | 5265 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24648 | Pre-made Rat Serpina1/Pi/AAT siRNA oligo Duplex | 24648 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701361 | Pre-made Cynomolgus/Rhesus macaque SERPINA1 siRNA oligo Duplex | 701361 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480422 | Pre-made Dog/Canine SERPINA1 siRNA oligo Duplex | 480422 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280699 | Pre-made Bovines/Cattle SERPINA1/PI siRNA oligo Duplex | 280699 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T28265-Ab | Human | Anti-Human Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T28265-Ab | Rat | Anti-Rat Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T28265-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T28265-Ab | Dog/Canine | Anti-Dog/Canine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T28265-Ab | Bovines/Cattle | Anti-Bovines/Cattle Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T28265-Ag | Human | Human Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T28265-Ag | Rat | Rat Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T28265-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T28265-Ag | Dog/Canine | Dog/Canine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T28265-Ag | Bovines/Cattle | Bovines/Cattle Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 recombinant protein | Mammalian cell | Detail |
