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Recombinant multi-species Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]
The Alternative Names of target: A1A,A1AT,AAT,Alpha 1 Antitrypsin,Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Alpha-1-antitrypsin,PI,PI1,PRO2275,Pi,SERPINA1,Serpin A1,Serpina1,Spi1,alpha1AT,nNIF
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28265-Ag-1/ GM-Tg-hg-T28265-Ag-2 | Human Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Human |
| GM-Tg-rg-T28265-Ag-1/ GM-Tg-rg-T28265-Ag-2 | Rat Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Rat |
| GM-Tg-mg-T28265-Ag-1/ GM-Tg-mg-T28265-Ag-2 | Mouse Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Mouse |
| GM-Tg-cynog-T28265-Ag-1/ GM-Tg-cynog-T28265-Ag-2 | Cynomolgus/Rhesus macaque Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28265-Ag-1/ GM-Tg-felg-T28265-Ag-2 | Feline Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Feline |
| GM-Tg-cang-T28265-Ag-1/ GM-Tg-cang-T28265-Ag-2 | Canine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Canine |
| GM-Tg-bovg-T28265-Ag-1/ GM-Tg-bovg-T28265-Ag-2 | Bovine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Bovine |
| GM-Tg-equg-T28265-Ag-1/ GM-Tg-equg-T28265-Ag-2 | Equine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T28265-Ag-1/ GM-Tg-hg-T28265-Ag-2;
GM-Tg-rg-T28265-Ag-1/ GM-Tg-rg-T28265-Ag-2;
GM-Tg-mg-T28265-Ag-1/ GM-Tg-mg-T28265-Ag-2; GM-Tg-cynog-T28265-Ag-1/ GM-Tg-cynog-T28265-Ag-2; GM-Tg-felg-T28265-Ag-1/ GM-Tg-felg-T28265-Ag-2; GM-Tg-cang-T28265-Ag-1/ GM-Tg-cang-T28265-Ag-2; GM-Tg-bovg-T28265-Ag-1/ GM-Tg-bovg-T28265-Ag-2; GM-Tg-equg-T28265-Ag-1/ GM-Tg-equg-T28265-Ag-2 |
| Products Name | Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Alpha 1 Antitrypsin/Alpha-1-antitrypsin/SERPINA1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.