Market Intelligence, Clinical Progress, and High-Purity Reagents for Next-Generation Immuno-Oncology Development.
TarMart Solution Ecosystem & Related Targets
Comprehensive reagent toolkit for TIGIT drug discovery. Select your modality below:
| Component / Network | Product Description | Product Link |
|---|---|---|
| Antigen | TIGIT ECD-Fc Fusion Protein High purity (>95%), Endotoxin <1EU/μg. Sequence Verified. HEK293 expressed for native glycosylation. |
View TIGIT Products |
| Gene Delivery | TIGIT Lentivirus Particles Full-length ORF for stable cell line generation. High titer, P2 packaging system. |
View TIGIT Products |
| Benchmark Ab | Anti-TIGIT (Tiragolumab Biosimilar) Recombinant positive control, sequence verified, endotoxin controlled. |
View TIGIT Products |
| Validator | TIGIT siRNA Set For knockdown verification and assay specificity controls. Sequence-verified targets. |
View TIGIT Products |
| Primary Ligand | PVR (CD155) Recombinant Protein Primary binding partner. ECD-Fc format available for SPR/BLI. |
View CD155 Products |
| Related Target A | PD-1 (PDCD1) Critical synergistic immune checkpoint for combination therapies. |
View PDCD1 Products |
| Related Target B | PVRIG (CD112R) Protein Parallel immune checkpoint for combination strategy evaluation. |
View PVRIG Products |
Critical Assay Challenges & TarMart Advantages
| Critical Assay Challenge | The TarMart Advantage (Technical Spec) |
|---|---|
| Cross-species bridging (Human/Cyno/Mouse) | Human/Mouse/Cynomolgus TIGIT ortholog proteins available with >95% purity; sequence verified for epitope conservation analysis. |
| Ligand blocking / competition (vs. CD226, CD96, PVRIG) | High-purity PVR/CD155, CD112, CD226, and PVRIG proteins for competitive binding SPR/BLI assays. |
| Fc engineering validation | TIGIT ECD-Fc with wild-type and effector-null Fc backbones available (LALA/aglycosylated options). |
| Internalization assessment (for ADC) | TIGIT Lentivirus for stable overexpression in target cell lines; compatible with pH-dependent tracer internalization assays. |
| Specificity controls & false positive reduction | Validated siRNA included for target-specificity verification; clinical benchmark antibodies (Tiragolumab biosimilar) provided as positive controls. |
Live TIGIT R&D Tracker
Market data changes daily. Access the latest global pipeline status directly:
Global Clinical Landscape & Future Outlook
The race for TIGIT therapeutics is intensifying, with major players shifting focus from monotherapy to strategic combinations. Following Phase 3 setbacks with first-generation antibodies (e.g., Roche's Tiragolumab in SKYSCRAPER trials), the field is pivoting toward Fc-engineered silenced mAbs and bispecific formats targeting TIGIT/PD-1 axes. As biomarker-driven strategies (CD155-high expression) emerge, the next wave of R&D targets optimal Fc-effector function, selective epitope engagement, and reduced peripheral toxicity through affinity tuning. Overcoming resistance in non-small cell lung cancer (NSCLC) and other solid tumors remains a key priority.
Competitive Modality & Indication Snapshot
| Modality | Representative Players | Key Indications | Critical Assay Need (Why TarMart?) |
|---|---|---|---|
| Fc-silenced mAb (Monoclonal Antibody) | Roche, GSK, Arcus/Gilead, Merck | NSCLC, Esophageal Cancer, Solid Tumors | FcγR binding assay (need WT vs Null Fc controls); high-purity ECD-Fc for structural studies. View TIGIT Products |
| Anti-TIGIT/PD-1 Bispecific | AstraZeneca, Akeso, BioNTech, Compugen | Advanced Solid Tumors | Heterodimer validation (need TIGIT + PD-1 co-binding); cross-reactive reagents for dual-construct assays. View TIGIT Products |
| ADC | Emergent Biotech | Metastatic Solid Tumors | Internalization Assay (need Lentivirus-stable overexpression lines); pH-sensitive tracer assays. View TIGIT Products |
| Combination Therapy | BeiGene, Bristol Myers Squibb, AstraZeneca | Immunotherapy Refractory, Relapsed/Refractory Cancers | Combination index assays with CD155/PVRIG pathways; receptor competition assays need PVR/CD155 antigens. View CD155 Products |