Explore PD-1/CD279/PDCD1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T59631
|
| Target Name |
PD-1/CD279/PDCD1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5133
|
| Gene ID |
100067948 (Equus caballus), 100135770 (Felis catus), 100135775 (Macaca mulatta), 18566 (Mus musculus)
301626 (Rattus norvegicus), 486213 (Canis lupus familiaris), 5133 (Homo sapiens), 613842 (Bos taurus)
|
| Target Alternative Names |
PDCD1,Pdcd1,PD-1,PD1,Pdc1,Ly101,CD279,SLEB2,hPD-1,hPD-l,hSLE1,AIMTBS
|
| Uniprot Accession |
Q02242,Q15116
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Cell adhesion molecules, T cell receptor signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000023275, ENSMMUG00000063159, ENSMUSG00000026285, ENSCAFG00845024308, ENSG00000188389, ENSBTAG00000011543
|
| Target Classification |
Checkpoint-Immuno Oncology, Cytokine Receptor, Pathway, Tumor-associated antigen (TAA)
|
Pre-made viral vector of PD-1/CD279/PDCD1 cDNA Clones/ORF Plasmid
PD-1/CD279/PDCD1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5133 | Pre-made Human PDCD1/PD1/PD-1 siRNA oligo Duplex | 5133 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo301626 | Pre-made Rat Pdcd1 siRNA oligo Duplex | 301626 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18566 | Pre-made Mouse Pdcd1/PD-1/Pdc1 siRNA oligo Duplex | 18566 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100135775 | Pre-made Cynomolgus/Rhesus macaque PDCD1/PD1 siRNA oligo Duplex | 100135775 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100135770 | Pre-made Cat/Feline PDCD1/PD-1 siRNA oligo Duplex | 100135770 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486213 | Pre-made Dog/Canine PDCD1/PD-1 siRNA oligo Duplex | 486213 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613842 | Pre-made Bovines/Cattle PDCD1/PD-1 siRNA oligo Duplex | 613842 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067948 | Pre-made Equine/Horse PDCD1/PD-1 siRNA oligo Duplex | 100067948 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PD-1/CD279/PDCD1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T59631-Ab | Human | Anti-Human PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T59631-Ab | Rat | Anti-Rat PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T59631-Ab | Mouse | Anti-Mouse PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T59631-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T59631-Ab | Cat/Feline | Anti-Cat/Feline PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T59631-Ab | Dog/Canine | Anti-Dog/Canine PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T59631-Ab | Bovines/Cattle | Anti-Bovines/Cattle PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T59631-Ab | Equine/Horse | Anti-Equine/Horse PD-1/CD279/PDCD1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PD-1/CD279/PDCD1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T59631-Ag | Human | Human PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T59631-Ag | Rat | Rat PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T59631-Ag | Mouse | Mouse PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T59631-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T59631-Ag | Cat/Feline | Cat/Feline PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T59631-Ag | Dog/Canine | Dog/Canine PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T59631-Ag | Bovines/Cattle | Bovines/Cattle PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T59631-Ag | Equine/Horse | Equine/Horse PD-1/CD279/PDCD1 VLP (virus-like particle) | HEK293 | Products Developing |
