Market Intelligence, Clinical Progress, and High-Purity Reagents for Immuno-Oncology and Autoimmune Disease Development.
TarMart Solution Ecosystem & Related Targets
Comprehensive reagent toolkit for CD122/IL-2RB drug discovery. Select your modality below:
| Component / Network | Product Description | Product Link |
|---|---|---|
| Antigen | CD122 (IL2RB) ECD-Fc Fusion Protein High purity (>95%), Endotoxin <1 EU/µg. Sequence Verified. HEK293 Expressed (Native Glycosylation). Theoretical MW confirmed. |
View IL2RB Products |
| Gene Delivery | IL2RB Promise-ORF / Lentivirus Full-length human ORF for stable cell line generation. HEK293T packaged. Sequence Verified. |
View IL2RB Products |
| Benchmark Ab | Anti-CD122 (IL2RB) Reference Antibody Recombinant positive control for binding, blocking, and occupancy assays. |
View IL2RB Products |
| Validator | IL2RB siRNA Set For knockdown verification and target dependency controls. |
View IL2RB Products |
| Co-receptor | IL2RG (Common Gamma Chain) Required for functional IL-2/IL-15 signaling complex. ECD-Fc available. |
View IL2RG Products |
| Related Target | IL2RA (CD25) Alpha subunit of IL-2 receptor, defines high-affinity IL-2 signaling; key for Treg-sparing selectivity profiling. |
View IL2RA Products |
| Related Target | IL15RA IL-15 specific receptor alpha, for competitive pathway analysis and IL-2/IL-15 selectivity. |
View IL15RA Products |
Critical Assay Challenges & TarMart Advantage
| Critical Assay Challenge | The TarMart Advantage (Technical Spec) |
|---|---|
| Receptor Selectivity Profiling (CD122 vs CD25) and Heterodimeric Assembly (CD122 + CD132) | Human / Cyno / Mouse CD122, CD25, CD132 ECD-Fc ortholog proteins available with >95% purity; sequence verified by mass spec. |
| IL-2 vs IL-15 Selectivity Screening | Cross-species ortholog proteins and CD122/IL15RA dual-antigen panel for competition assays. |
| Treg vs Effector Cell Bias Validation | High-concentration stability proteins for SPR/BLI affinity tuning and STAT5 phosphorylation assays. |
| Lack of Cross-Species Assay Controls | Clinical Benchmark Antibodies and ortholog antigens included for rodent and NHP translation. |
| False Positives in Binding Assays | Validated siRNA included for CD122-specificity checks and target dependency confirmation. |
Live CD122 R&D Tracker
Market data changes daily. Access the latest global pipeline status directly:
Global Clinical Landscape & Future Outlook
The race for CD122-targeted therapeutics is intensifying, with major players shifting focus from traditional high-dose IL-2 to engineered cytokine muteins and CD122-biased agonists. As first-generation therapies (such as Roche's nemvaleukin alpha) advance through Phase 2 trials in combination with checkpoint inhibitors, the next wave of R&D is targeting differentiated receptor geometry—specifically bypassing IL-2Rα (CD25) to spare regulatory T cells while maximizing effector T-cell and NK-cell expansion. This evolution demands reagents that accurately model the heterodimeric CD122/CD132 interface and enable rigorous selectivity profiling against the trimeric IL-2 receptor complex. In autoimmune indications, biased agonism towards CD25/CD122 is explored to expand Tregs without systemic toxicity.
Competitive Modality & Indication Snapshot
| Modality | Representative Players | Key Indications | Critical Assay Need (Why TarMart?) |
|---|---|---|---|
| Engineered Cytokine (IL-2 Mutein, CD122-biased) | Roche, Synthekine, Alkermes, Medicenna | Solid Tumors (Ovarian, Renal), Melanoma | Receptor Selectivity Assay (Need high-purity CD122 vs IL2RA proteins) |
| Anti-CD122 Antibody (Depleting/Agonist) | Biotech Startups, Academia | Autoimmune (Treg expansion), Transplantation | Internalization Assay (Need stable CD122+ cell lines via Lentivirus) |
| Bispecific Cytokine / Immunocytokine | Synthekine, Pfizer, Roche | Immunotherapy combinations, Advanced Melanoma | Heterodimer Validation (Need cross-reactive Abs for PK/PD and ortholog proteins) |
| Cell Therapy (CAR-T) | Academic Institutions | Hematologic Malignancies | Expression Validation (Need CD122 Lentivirus for transduction) |