Explore IL-15RA/IL15RA/CD215 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
| Target ID |
GM-T48429
|
| Target Name |
IL-15RA/IL15RA/CD215
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3601
|
| Gene ID |
100070311 (Equus caballus), 101082243 (Felis catus), 16169 (Mus musculus), 3601 (Homo sapiens) 487141 (Canis lupus familiaris), 615030 (Bos taurus), 690369 (Rattus norvegicus), 712788 (Macaca mulatta)
|
| Target Alternative Names |
CD215,IL-15 receptor subunit alpha,IL-15R-alpha,IL-15RA,IL15RA,Il15ra,Interleukin-15 receptor subunit alpha
|
| Uniprot Accession |
Q60819,Q13261
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
Lung Cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Intestinal immune network for IgA production, Human T-cell leukemia virus 1 infection, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000006776, ENSMUSG00000023206, ENSG00000134470, ENSCAFG00845002159, ENSBTAG00000006078, ENSMMUG00000015149
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of IL-15RA/IL15RA/CD215 cDNA Clones/ORF Plasmid
IL-15RA/IL15RA/CD215 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3601 | Pre-made Human IL15RA/CD215 siRNA oligo Duplex | 3601 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo690369 | Pre-made Rat Il15ra siRNA oligo Duplex | 690369 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16169 | Pre-made Mouse Il15ra/IL-15RA siRNA oligo Duplex | 16169 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712788 | Pre-made Cynomolgus/Rhesus macaque IL15RA siRNA oligo Duplex | 712788 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082243 | Pre-made Cat/Feline IL15RA siRNA oligo Duplex | 101082243 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487141 | Pre-made Dog/Canine IL15RA siRNA oligo Duplex | 487141 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo615030 | Pre-made Bovines/Cattle IL15RA siRNA oligo Duplex | 615030 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070311 | Pre-made Equine/Horse IL15RA siRNA oligo Duplex | 100070311 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-15RA/IL15RA/CD215 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T48429-Ab | Human | Anti-Human IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T48429-Ab | Rat | Anti-Rat IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T48429-Ab | Mouse | Anti-Mouse IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T48429-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T48429-Ab | Cat/Feline | Anti-Cat/Feline IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T48429-Ab | Dog/Canine | Anti-Dog/Canine IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T48429-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T48429-Ab | Equine/Horse | Anti-Equine/Horse IL-15RA/IL15RA/CD215 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
IL-15RA/IL15RA/CD215 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T48429-Ag | Human | Human IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T48429-Ag | Rat | Rat IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T48429-Ag | Mouse | Mouse IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T48429-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T48429-Ag | Cat/Feline | Cat/Feline IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T48429-Ag | Dog/Canine | Dog/Canine IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T48429-Ag | Bovines/Cattle | Bovines/Cattle IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T48429-Ag | Equine/Horse | Equine/Horse IL-15RA/IL15RA/CD215 VLP (virus-like particle) | HEK293 | Products Developing |