Explore CD122/IL-2RB/IL2RB gene products and cross-species
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Target
sublocation: Transmembrane Protein.
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]
| Target ID |
GM-T19579
|
| Target Name |
CD122/IL-2RB/IL2RB
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3560
|
| Gene ID |
100069676 (Equus caballus), 101092622 (Felis catus), 104968644 (Bos taurus), 16185 (Mus musculus) 25746 (Rattus norvegicus), 3560 (Homo sapiens), 403439 (Canis lupus familiaris), 696331 (Macaca mulatta)
|
| Target Alternative Names |
CD122,High affinity IL-2 receptor subunit beta,IL-15Rbeta,IL-2 receptor subunit beta,IL-2R subunit beta,IL-2RB,IL15RB,IL15Rbeta,IL2RB,IL2RBC,IMD63,Il-2/15Rbeta,Il-2Rbeta,Il2rb,Interleukin-15 receptor subunit beta,Interleukin-2 receptor subunit beta,P70-75,p70,p70-75 (p75)
|
| Uniprot Accession |
P16297,P26896,P14784
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000016033, ENSBTAG00000016345, ENSMUSG00000068227, ENSG00000100385, ENSCAFG00845007511, ENSMMUG00000005417
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD122/IL-2RB/IL2RB cDNA Clones/ORF Plasmid
CD122/IL-2RB/IL2RB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3560 | Pre-made Human IL2RB/CD122/IMD63 siRNA oligo Duplex | 3560 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25746 | Pre-made Rat Il2rb/IL2RBC siRNA oligo Duplex | 25746 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16185 | Pre-made Mouse Il2rb/p70/CD122 siRNA oligo Duplex | 16185 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696331 | Pre-made Cynomolgus/Rhesus macaque IL2RB siRNA oligo Duplex | 696331 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092622 | Pre-made Cat/Feline IL2RB siRNA oligo Duplex | 101092622 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403439 | Pre-made Dog/Canine IL2RB siRNA oligo Duplex | 403439 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo104968644 | Pre-made Bovines/Cattle IL2RB siRNA oligo Duplex | 104968644 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100069676 | Pre-made Equine/Horse IL2RB siRNA oligo Duplex | 100069676 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD122/IL-2RB/IL2RB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T19579-Ab | Human | Anti-Human CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T19579-Ab | Rat | Anti-Rat CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T19579-Ab | Mouse | Anti-Mouse CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T19579-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T19579-Ab | Cat/Feline | Anti-Cat/Feline CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T19579-Ab | Dog/Canine | Anti-Dog/Canine CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T19579-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T19579-Ab | Equine/Horse | Anti-Equine/Horse CD122/IL-2RB/IL2RB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD122/IL-2RB/IL2RB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T19579-Ag | Human | Human CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T19579-Ag | Rat | Rat CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T19579-Ag | Mouse | Mouse CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T19579-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T19579-Ag | Cat/Feline | Cat/Feline CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T19579-Ag | Dog/Canine | Dog/Canine CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T19579-Ag | Bovines/Cattle | Bovines/Cattle CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T19579-Ag | Equine/Horse | Equine/Horse CD122/IL-2RB/IL2RB VLP (virus-like particle) | HEK293 | Products Developing |