Explore IL-12/IL12A gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Target ID |
GM-T13251
|
Target Name |
IL-12/IL12A
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3592
|
Gene ID |
100034215 (Equus caballus), 16159 (Mus musculus), 281856 (Bos taurus), 3592 (Homo sapiens) 403977 (Canis lupus familiaris), 493741 (Felis catus), 703205 (Macaca mulatta), 84405 (Rattus norvegicus)
|
Target Alternative Names |
IL12A,Il12a,IL-12A,p35,Ll12a,Il-12a,IL-12p35,IL12p35,Il-12 p35,P35,CLMF,NFSK,NKSF1,CLMF p35
|
Uniprot Accession |
Q9XSQ6,P43431,P54349,P29459,Q28267,O02743,P48091,Q9R103
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target, Cytokine Target
|
Disease |
cancer, malignant glioma
|
Disease from KEGG |
Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Alcoholic liver disease, Type I diabetes mellitus, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Measles, Influenza A, Pathways in cancer, Inflammatory bowel disease, Allograft rejection, Lipid and atherosclerosis
|
Gene Ensembl |
ENSECAG00000024671, ENSMUSG00000027776, ENSBTAG00000015150, ENSG00000168811, ENSCAFG00845026803, ENSMMUG00000023084
|
Target Classification |
|
Pre-made viral vector of IL-12/IL12A cDNA Clones/ORF Plasmid
IL-12/IL12A siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo3592 | Pre-made Human IL12A/P35/CLMF siRNA oligo Duplex | 3592 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo84405 | Pre-made Rat Il12a siRNA oligo Duplex | 84405 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo16159 | Pre-made Mouse Il12a/p35/Ll12a siRNA oligo Duplex | 16159 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo703205 | Pre-made Cynomolgus/Rhesus macaque IL12A/IL-12A siRNA oligo Duplex | 703205 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo493741 | Pre-made Cat/Feline IL12A siRNA oligo Duplex | 493741 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo403977 | Pre-made Dog/Canine IL12A/CLMF p35 siRNA oligo Duplex | 403977 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo281856 | Pre-made Bovines/Cattle IL12A/IL12p35/Il-12 p35 siRNA oligo Duplex | 281856 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100034215 | Pre-made Equine/Horse IL12A/IL-12A siRNA oligo Duplex | 100034215 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-12/IL12A antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T13251-Ab | Human | Anti-Human IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T13251-Ab | Rat | Anti-Rat IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T13251-Ab | Mouse | Anti-Mouse IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T13251-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T13251-Ab | Cat/Feline | Anti-Cat/Feline IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T13251-Ab | Dog/Canine | Anti-Dog/Canine IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T13251-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T13251-Ab | Equine/Horse | Anti-Equine/Horse IL-12/IL12A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IL-12/IL12A recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T13251-Ag | Human | Human IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T13251-Ag | Rat | Rat IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T13251-Ag | Mouse | Mouse IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T13251-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T13251-Ag | Cat/Feline | Cat/Feline IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T13251-Ag | Dog/Canine | Dog/Canine IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T13251-Ag | Bovines/Cattle | Bovines/Cattle IL-12/IL12A recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T13251-Ag | Equine/Horse | Equine/Horse IL-12/IL12A recombinant protein | Mammalian cell | Detail |