Recombinant multi-species IL-12/IL12A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-12/IL12A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
The Alternative Names of target: IL-12, IL12A,Interleukin-12 subunit alpha,IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit (CLMF p35), IL-12 subunit p35, NK cell stimulatory factor chain 1 (NKSF1),P35,CLMF,NFSK,NKSF1,IL-12A

Target products collectionGo to IL-12/IL12A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T13251-Ab-1/ GM-Tg-hg-T13251-Ab-2 Human IL-12/IL12A protein Human
GM-Tg-rg-T13251-Ab-1/ GM-Tg-rg-T13251-Ab-2 Rat IL-12/IL12A protein Rat
GM-Tg-mg-T13251-Ab-1/ GM-Tg-mg-T13251-Ab-2 Mouse IL-12/IL12A protein Mouse
GM-Tg-cynog-T13251-Ab-1/ GM-Tg-cynog-T13251-Ab-2 Cynomolgus/Rhesus macaque IL-12/IL12A monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T13251-Ab-1/ GM-Tg-felg-T13251-Ab-2 Feline IL-12/IL12A protein Feline
GM-Tg-cang-T13251-Ab-1/ GM-Tg-cang-T13251-Ab-2 Canine IL-12/IL12A protein Canine
GM-Tg-bovg-T13251-Ab-1/ GM-Tg-bovg-T13251-Ab-2 Bovine IL-12/IL12A protein Bovine
GM-Tg-equg-T13251-Ab-1/ GM-Tg-equg-T13251-Ab-2 Equine IL-12/IL12A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T13251-Ab-1/ GM-Tg-hg-T13251-Ab-2; GM-Tg-rg-T13251-Ab-1/ GM-Tg-rg-T13251-Ab-2;
GM-Tg-mg-T13251-Ab-1/ GM-Tg-mg-T13251-Ab-2; GM-Tg-cynog-T13251-Ab-1/ GM-Tg-cynog-T13251-Ab-2;
GM-Tg-felg-T13251-Ab-1/ GM-Tg-felg-T13251-Ab-2; GM-Tg-cang-T13251-Ab-1/ GM-Tg-cang-T13251-Ab-2;
GM-Tg-bovg-T13251-Ab-1/ GM-Tg-bovg-T13251-Ab-2; GM-Tg-equg-T13251-Ab-1/ GM-Tg-equg-T13251-Ab-2
Products Name IL-12/IL12A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-12/IL12A
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-12/IL12A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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