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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
| Target ID |
GM-SE0506
|
| Target Name |
TIMP1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7076
|
| Gene ID |
100034220 (Equus caballus), 101095886 (Felis catus), 116510 (Rattus norvegicus), 21857 (Mus musculus) 282092 (Bos taurus), 403816 (Canis lupus familiaris), 574348 (Macaca mulatta), 7076 (Homo sapiens)
|
| Target Alternative Names |
CLGI,Clgi,EPA,EPO,Erythroid-potentiating activity (EPA),Fibroblast collagenase inhibitor (Collagenase inhibitor),HCI,Metalloproteinase inhibitor 1,TIMP,TIMP-1,TIMP1,TPA-S1,Timp,Timp1,Tissue inhibitor of metalloproteinases 1 (TIMP-1)
|
| Uniprot Accession |
O02722,P30120,P12032,P20414,P81546,Q95KL9,P01033
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Diagnostics Biomarker
|
| Disease |
cancer, Dent disease, Vesicoureteral reflux
|
| Disease from KEGG |
HIF-1 signaling pathway
|
| Gene Ensembl |
ENSECAG00000014259, ENSMUSG00000001131, ENSBTAG00000066152, ENSCAFG00845030572, ENSMMUG00000011426, ENSG00000102265
|
Pre-made viral vector of TIMP1 cDNA Clones/ORF Plasmid
TIMP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7076 | Pre-made Human TIMP1/EPA/EPO siRNA oligo Duplex | 7076 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116510 | Pre-made Rat Timp1/Timp/TIMP-1 siRNA oligo Duplex | 116510 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21857 | Pre-made Mouse Timp1/EPA/Clgi siRNA oligo Duplex | 21857 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574348 | Pre-made Cynomolgus/Rhesus macaque TIMP1/TIMP-1 siRNA oligo Duplex | 574348 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095886 | Pre-made Cat/Feline TIMP1 siRNA oligo Duplex | 101095886 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403816 | Pre-made Dog/Canine TIMP1/TIMP-1 siRNA oligo Duplex | 403816 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282092 | Pre-made Bovines/Cattle TIMP1 siRNA oligo Duplex | 282092 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034220 | Pre-made Equine/Horse TIMP1/TIMP-1 siRNA oligo Duplex | 100034220 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TIMP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0506-Ab | Human | Anti-Human TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-SE0506-Ab | Rat | Anti-Rat TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-SE0506-Ab | Mouse | Anti-Mouse TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-SE0506-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-SE0506-Ab | Cat/Feline | Anti-Cat/Feline TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-SE0506-Ab | Dog/Canine | Anti-Dog/Canine TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-SE0506-Ab | Bovines/Cattle | Anti-Bovines/Cattle TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-SE0506-Ab | Equine/Horse | Anti-Equine/Horse TIMP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
TIMP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0506-Ag | Human | Human TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0506-Ag | Rat | Rat TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0506-Ag | Mouse | Mouse TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0506-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0506-Ag | Cat/Feline | Cat/Feline TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0506-Ag | Dog/Canine | Dog/Canine TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0506-Ag | Bovines/Cattle | Bovines/Cattle TIMP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0506-Ag | Equine/Horse | Equine/Horse TIMP1 recombinant protein | Mammalian cell | Detail |