Recombinant multi-species TIMP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TIMP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CLGI,Clgi,EPA,EPO,Erythroid-potentiating activity (EPA),Fibroblast collagenase inhibitor (Collagenase inhibitor),HCI,Metalloproteinase inhibitor 1,TIMP,TIMP-1,TIMP1,TPA-S1,Timp,Timp1,Tissue inhibitor of metalloproteinases 1 (TIMP-1)

Target products collectionGo to TIMP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0506-Ag-1/ GM-Tg-hg-SE0506-Ag-2 Human TIMP1 protein Human
GM-Tg-rg-SE0506-Ag-1/ GM-Tg-rg-SE0506-Ag-2 Rat TIMP1 protein Rat
GM-Tg-mg-SE0506-Ag-1/ GM-Tg-mg-SE0506-Ag-2 Mouse TIMP1 protein Mouse
GM-Tg-cynog-SE0506-Ag-1/ GM-Tg-cynog-SE0506-Ag-2 Cynomolgus/Rhesus macaque TIMP1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0506-Ag-1/ GM-Tg-felg-SE0506-Ag-2 Feline TIMP1 protein Feline
GM-Tg-cang-SE0506-Ag-1/ GM-Tg-cang-SE0506-Ag-2 Canine TIMP1 protein Canine
GM-Tg-bovg-SE0506-Ag-1/ GM-Tg-bovg-SE0506-Ag-2 Bovine TIMP1 protein Bovine
GM-Tg-equg-SE0506-Ag-1/ GM-Tg-equg-SE0506-Ag-2 Equine TIMP1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0506-Ag-1/ GM-Tg-hg-SE0506-Ag-2; GM-Tg-rg-SE0506-Ag-1/ GM-Tg-rg-SE0506-Ag-2;
GM-Tg-mg-SE0506-Ag-1/ GM-Tg-mg-SE0506-Ag-2; GM-Tg-cynog-SE0506-Ag-1/ GM-Tg-cynog-SE0506-Ag-2;
GM-Tg-felg-SE0506-Ag-1/ GM-Tg-felg-SE0506-Ag-2; GM-Tg-cang-SE0506-Ag-1/ GM-Tg-cang-SE0506-Ag-2;
GM-Tg-bovg-SE0506-Ag-1/ GM-Tg-bovg-SE0506-Ag-2; GM-Tg-equg-SE0506-Ag-1/ GM-Tg-equg-SE0506-Ag-2
Products Name TIMP1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TIMP1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TIMP1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.