Explore IL-5/IL5 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
| Target ID |
GM-T78585
|
| Target Name |
IL-5/IL5
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3567
|
| Gene ID |
100034199 (Equus caballus), 16191 (Mus musculus), 24497 (Rattus norvegicus), 280825 (Bos taurus) 3567 (Homo sapiens), 403790 (Canis lupus familiaris), 493803 (Felis catus), 710622 (Macaca mulatta)
|
| Target Alternative Names |
B-cell differentiation factor I,EDF,Eosinophil differentiation factor,IL-5,IL5,Il-5,Il5,Interleukin-5,T-cell replacing factor (TRF),TRF
|
| Uniprot Accession |
O02699,P04401,Q08125,P52173,P05113,Q95J76,O77515,P48093
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
Hodgkin's disease, Overactive bladder
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Intestinal immune network for IgA production, Pathways in cancer, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Allograft rejection
|
| Gene Ensembl |
ENSECAG00000016648, ENSMUSG00000036117, ENSBTAG00000031235, ENSG00000113525, ENSCAFG00845010566, ENSMMUG00000051989
|
Pre-made viral vector of IL-5/IL5 cDNA Clones/ORF Plasmid
IL-5/IL5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3567 | Pre-made Human IL5/EDF/TRF siRNA oligo Duplex | 3567 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24497 | Pre-made Rat Il5 siRNA oligo Duplex | 24497 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16191 | Pre-made Mouse Il5/Il-5 siRNA oligo Duplex | 16191 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710622 | Pre-made Cynomolgus/Rhesus macaque IL5/TRF siRNA oligo Duplex | 710622 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493803 | Pre-made Cat/Feline IL5 siRNA oligo Duplex | 493803 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403790 | Pre-made Dog/Canine IL5 siRNA oligo Duplex | 403790 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280825 | Pre-made Bovines/Cattle IL5/TRF/IL-5 siRNA oligo Duplex | 280825 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034199 | Pre-made Equine/Horse IL5/IL-5 siRNA oligo Duplex | 100034199 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-5/IL5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T78585-Ab | Human | Anti-Human IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T78585-Ab | Rat | Anti-Rat IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T78585-Ab | Mouse | Anti-Mouse IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T78585-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T78585-Ab | Cat/Feline | Anti-Cat/Feline IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T78585-Ab | Dog/Canine | Anti-Dog/Canine IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T78585-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T78585-Ab | Equine/Horse | Anti-Equine/Horse IL-5/IL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
IL-5/IL5 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T78585-Ag | Human | Human IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T78585-Ag | Rat | Rat IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T78585-Ag | Mouse | Mouse IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T78585-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T78585-Ag | Cat/Feline | Cat/Feline IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T78585-Ag | Dog/Canine | Dog/Canine IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T78585-Ag | Bovines/Cattle | Bovines/Cattle IL-5/IL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T78585-Ag | Equine/Horse | Equine/Horse IL-5/IL5 recombinant protein | Mammalian cell | Detail |