NGAL/LCN2 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
| Target ID | GM-T72010 |
| Target Name | NGAL/LCN2 |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
3934 |
| Gene ID |
100070310 (Equus caballus), 16819 (Mus musculus), 170496 (Rattus norvegicus), 3934 (Homo sapiens) 491320 (Canis lupus familiaris), 526639 (Bos taurus), 697208 (Macaca mulatta) |
| Target Alternative Names | 24p3,25 kDa alpha-2-microglobulin-related subunit of MMP-9,LCN2,Lcn2,Lipocalin-2,MSFI,NGAL,NRL,Neutrophil gelatinase-associated lipocalin,Oncogene 24p3,Siderocalin,Sip24,p25 |
| Uniprot Accession | P11672,P30152,P80188 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | cancer, Prostate Cancer, Complications of kidney transplant, Congenital hydronephrosis, Congenital occlusion of ureteropelvic junction, Contact with and (suspected) exposure to hazardous aromatic compounds, Contrast - Induced Nephropathy, Delayed Graft Function, Dent disease, Diabetic Nephropathy, HIV-Associated Nephropathy, Hydronephrosis, Hypertension, Impaired renal function disease, Injury to Kidney, Intraoperative Renal Injury, Kidney transplant rejection, Lupus Glomerulonephritis, Neonatal urinary tract infection, Nephrectomy, Nephropathy induced by other drugs, medicaments and biological substances, Nephrotic syndrome, Nephrotic syndrome with diffuse membranous glomerulonephritis, Proteinuria, Renal fibrosis, Renovascular hypertension, Sepsis due to Enterococcus, Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction, Systemic lupus erythematosus (SLE), Transplanted Heart Complication, Type 1 diabetes mellitus with diabetic nephropathy, Acute pancreatitis, Asphyxia neonatorum, Autosomal Dominant Polycystic Kidney Disease, Cardiogenic shock, Chronic Kidney Disease, Type 2 diabetes mellitus, Vasculitis, Vesicoureteral reflux |
| Disease from KEGG | IL-17 signaling pathway |
| Gene Ensembl | ENSECAG00000020957, ENSMUSG00000026822, ENSG00000148346, ENSCAFG00845029755, ENSBTAG00000014149, ENSMMUG00000023801 |
Pre-made viral vector of NGAL/LCN2 cDNA Clones/ORF Plasmid
| Cat No. | Product Name | NMID | GeneID | Species | Type | Marker | Fusion Tag | Promoter | Detail |
|---|---|---|---|---|---|---|---|---|---|
| pGMLP002859 | Human LCN2/24p3/MSFI Lentivirus plasmid | NM_005564 | 3934 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC000637 | Human LCN2/24p3/MSFI Mammalian (Non-Viral Vector) plasmid | NM_005564.5 | 3934 | Human | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAD001066 | Human LCN2/24p3/MSFI Adenovirus particle | NM_005564.5 | 3934 | Human | Adenovirus particle | Null | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV001321 | Human LCN2/24p3/MSFI Lentivirus particle | NM_005564 | 3934 | Human | Lentivirus particle | Firefly luciferase | 3xflag (C-Terminal) | CMV | Detail |
| vGMLP002859 | Human LCN2/24p3/MSFI Lentivirus particle | NM_005564 | 3934 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC001766 | Human LCN2/24p3/MSFI Mammalian (Non-Viral Vector) plasmid | NM_005564.5 | 3934 | Human | Mammalian (Non-Viral Vector) plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV001321 | Human LCN2/24p3/MSFI Lentivirus plasmid | NM_005564 | 3934 | Human | Lentivirus plasmid | Firefly luciferase | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC000792 | Human LCN2/24p3/MSFI Mammalian (Non-Viral Vector) plasmid | NM_005564.5 | 3934 | Human | Mammalian (Non-Viral Vector) plasmid | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC001300 | Human LCN2/24p3/MSFI Mammalian (Non-Viral Vector) plasmid | NM_005564.5 | 3934 | Human | Mammalian (Non-Viral Vector) plasmid | Null | HA (C-Terminal) | CMV | Detail |
| pGMAD001066 | Human LCN2/24p3/MSFI Adenovirus plasmid | NM_005564.5 | 3934 | Human | Adenovirus plasmid | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMAAV001609 | Rat Lcn2/Sip24 Adeno-associate virus(AAV) plasmid | NM_130741.1 | 170496 | Rat | Adeno-associate virus(AAV) plasmid | ZsGreen | 3xflag (C-Terminal) | SM22a | Detail |
| vGMAAV001609 | Rat Lcn2/Sip24 Adeno-associate virus(AAV) particle | NM_130741.1 | 170496 | Rat | Adeno-associate virus(AAV) particle | ZsGreen | 3xflag (C-Terminal) | SM22a | Detail |
| pGMAAV000092 | Rat Lcn2/Sip24 Adeno-associate virus(AAV) plasmid | NM_130741.1 | 170496 | Rat | Adeno-associate virus(AAV) plasmid | GFP | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC001508 | Rat Lcn2/Sip24 Mammalian (Non-Viral Vector) plasmid | NM_130741.1 | 170496 | Rat | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMPC001533 | Rat Lcn2/Sip24 Mammalian (Non-Viral Vector) plasmid | NM_130741.1 | 170496 | Rat | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAAV000092 | Rat Lcn2/Sip24 Adeno-associate virus(AAV) particle | NM_130741.1 | 170496 | Rat | Adeno-associate virus(AAV) particle | GFP | 3xflag (C-Terminal) | CMV | Detail |
| pGMAAV001688 | Mouse Lcn2/24p3/NRL Adeno-associate virus(AAV) plasmid | NM_008491.1 | 16819 | Mouse | Adeno-associate virus(AAV) plasmid | ZsGreen | 3xflag (C-Terminal) | SM22a | Detail |
| vGMAD000811 | Mouse Lcn2/24p/24p3 Adenovirus particle | NM_008491 | 16819 | Mouse | Adenovirus particle | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMAAV001688 | Mouse Lcn2/24p3/NRL Adeno-associate virus(AAV) particle | NM_008491.1 | 16819 | Mouse | Adeno-associate virus(AAV) particle | ZsGreen | 3xflag (C-Terminal) | SM22a | Detail |
| vGMAAV000860 | Mouse Lcn2/24p/24p3 Adeno-associate virus(AAV) particle | NM_008491.1 | 16819 | Mouse | Adeno-associate virus(AAV) particle | EGFP | 3xflag (C-Terminal) | GFAP | Detail |
| pGMLV001694 | Mouse Lcn2/24p3/AW212229 Lentivirus plasmid | NM_008491.1 | 16819 | Mouse | Lentivirus plasmid | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV002728 | Mouse Lcn2/24p3/NRL Lentivirus plasmid | NM_008491.1 | 16819 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV002728 | Mouse Lcn2/24p3/NRL Lentivirus particle | NM_008491.1 | 16819 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV001694 | Mouse Lcn2/24p3/AW212229 Lentivirus particle | NM_008491.1 | 16819 | Mouse | Lentivirus particle | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMLPm001038 | Mouse Lcn2/24p3/AW212229 Lentivirus plasmid | NM_008491.1 | 16819 | Mouse | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMAD000811 | Mouse Lcn2/24p/24p3 Adenovirus plasmid | NM_008491 | 16819 | Mouse | Adenovirus plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMPC001070 | Mouse Lcn2/24p3/AW212229 Mammalian (Non-Viral Vector) plasmid | NM_008491.1 | 16819 | Mouse | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMAAV000860 | Mouse Lcn2/24p/24p3 Adeno-associate virus(AAV) plasmid | NM_008491.1 | 16819 | Mouse | Adeno-associate virus(AAV) plasmid | EGFP | 3xflag (C-Terminal) | GFAP | Detail |
| vGMLPm001038 | Mouse Lcn2/24p3/AW212229 Lentivirus particle | NM_008491.1 | 16819 | Mouse | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
NGAL/LCN2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|---|---|---|---|---|
| pGMoligo3934 | Pre-made Human LCN2/p25/24p3 siRNA oligo Duplex | 3934 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170496 | Pre-made Rat Lcn2/Sip24 siRNA oligo Duplex | 170496 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16819 | Pre-made Mouse Lcn2/NRL/24p3 siRNA oligo Duplex | 16819 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697208 | Pre-made Cynomolgus/Rhesus macaque LCN2 siRNA oligo Duplex | 697208 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491320 | Pre-made Dog/Canine LCN2 siRNA oligo Duplex | 491320 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo526639 | Pre-made Bovines/Cattle LCN2 siRNA oligo Duplex | 526639 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070310 | Pre-made Equine/Horse LCN2 siRNA oligo Duplex | 100070310 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NGAL/LCN2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|---|---|---|---|---|
| GM-Tg-hg-T72010-Ab | Human | Anti-Human NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-T72010-Ab | Rat | Anti-Rat NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T72010-Ab | Mouse | Anti-Mouse NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T72010-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T72010-Ab | Dog/Canine | Anti-Dog/Canine NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T72010-Ab | Bovines/Cattle | Anti-Bovines/Cattle NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T72010-Ab | Equine/Horse | Anti-Equine/Horse NGAL/LCN2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
NGAL/LCN2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|---|---|---|---|
| GM-Tg-hg-T72010-Ag | Human | Human NGAL/LCN2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T72010-Ag | Rat | Rat NGAL/LCN2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T72010-Ag | Mouse | Mouse NGAL/LCN2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T72010-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NGAL/LCN2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T72010-Ag | Dog/Canine | Dog/Canine NGAL/LCN2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T72010-Ag | Bovines/Cattle | Bovines/Cattle NGAL/LCN2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T72010-Ag | Equine/Horse | Equine/Horse NGAL/LCN2 recombinant protein | Mammalian cell | Detail |