PPP1CA Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore PPP1CA gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

Target ID GM-T59845
Target Name PPP1CA
Gene Group ldentifer
(Target Gene ID in Homo species)
5499
Gene ID 100059233 (Equus caballus), 109492306 (Felis catus), 19045 (Mus musculus), 24668 (Rattus norvegicus)
403609 (Canis lupus familiaris), 516175 (Bos taurus), 5499 (Homo sapiens), 721735 (Macaca mulatta)
Target Alternative Names PPP1CA,Ppp1ca,Ppp1c,dism2,PP1alpha,PP1A,PP-1A,PPP1A
Uniprot Accession P62137,P62138,Q8WMS6,Q3T0E7,P62136
Uniprot Entry Name
Protein Sub-location Transmembrane Protein
Category Therapeutics Target
Disease
Disease from KEGG cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Hippo signaling pathway, Focal adhesion, Platelet activation, Long-term potentiation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Insulin resistance, Amphetamine addiction, Proteoglycans in cancer
Gene Ensembl ENSECAG00000010532, ENSMUSG00000040385, ENSCAFG00845010538, ENSBTAG00000012146, ENSG00000172531, ENSMMUG00000017278
Target Classification Kinase


Pre-made viral vector of PPP1CA cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP000473Human PPP1CA/PP-1A/PP1A Lentivirus plasmidNM_0027085499HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLP005601Human PPP1CA/PP-1A/PP1A Lentivirus plasmidNM_002708.35499HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMAP000389Human PPP1CA/MGC15877/MGC1674 Adenovirus plasmidBC0018885499HumanAdenovirus plasmidGFP3xflag (C-Terminal)EF1Detail
pGMPC000448Human PPP1CA/PP-1A/PP1A Mammalian (Non-Viral Vector) plasmidNM_0027085499HumanMammalian (Non-Viral Vector) plasmidNullMYC (C-Terminal)CMVDetail
vGMLP000473Human PPP1CA/PP-1A/PP1A Lentivirus particleNM_0027085499HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLP005601Human PPP1CA/PP-1A/PP1A Lentivirus particleNM_002708.35499HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMAP000389Human PPP1CA/MGC15877/MGC1674 Adenovirus particleBC0018885499HumanAdenovirus particleGFP3xflag (C-Terminal)EF1Detail


PPP1CA siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo5499Pre-made Human PPP1CA/PP1A/PP-1A siRNA oligo Duplex5499HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo24668Pre-made Rat Ppp1ca/PP1alpha siRNA oligo Duplex24668RatIn-vitro grade; in-vivo gradeDetail
pGMoligo19045Pre-made Mouse Ppp1ca/Ppp1c/dism2 siRNA oligo Duplex19045MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo721735Pre-made Cynomolgus/Rhesus macaque PPP1CA siRNA oligo Duplex721735Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo109492306Pre-made Cat/Feline PPP1CA siRNA oligo Duplex109492306Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo403609Pre-made Dog/Canine PPP1CA siRNA oligo Duplex403609Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo516175Pre-made Bovines/Cattle PPP1CA siRNA oligo Duplex516175Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100059233Pre-made Equine/Horse PPP1CA siRNA oligo Duplex100059233Equine/HorseIn-vitro grade; in-vivo gradeDetail


PPP1CA antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T59845-AbHumanAnti-Human PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-rg-T59845-AbRatAnti-Rat PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-mg-T59845-AbMouseAnti-Mouse PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-cynog-T59845-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-felg-T59845-AbCat/FelineAnti-Cat/Feline PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-cang-T59845-AbDog/CanineAnti-Dog/Canine PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-bovg-T59845-AbBovines/CattleAnti-Bovines/Cattle PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-equg-T59845-AbEquine/HorseAnti-Equine/Horse PPP1CA monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail


PPP1CA VLP (virus-like particle)

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T59845-AgHumanHuman PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-rg-T59845-AgRatRat PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-mg-T59845-AgMouseMouse PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-cynog-T59845-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-felg-T59845-AgCat/FelineCat/Feline PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-cang-T59845-AgDog/CanineDog/Canine PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-bovg-T59845-AgBovines/CattleBovines/Cattle PPP1CA VLP (virus-like particle)HEK293Products Developing
GM-Tg-equg-T59845-AgEquine/HorseEquine/Horse PPP1CA VLP (virus-like particle)HEK293Products Developing