Explore BNP/NPPB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T55302
|
| Target Name |
BNP/NPPB
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4879
|
| Gene ID |
100056123 (Equus caballus), 18158 (Mus musculus), 25105 (Rattus norvegicus), 487441 (Canis lupus familiaris) 4879 (Homo sapiens), 493764 (Felis catus), 508734 (Bos taurus), 715053 (Macaca mulatta)
|
| Target Alternative Names |
BNF,BNP,Bnf,Brain natriuretic factor prohormone (preproBNP,Gamma-brain natriuretic peptide,Iso-ANP,NNX,NPPB,Natriuretic peptides B,Nppb,proBNP)
|
| Uniprot Accession |
P40753,P13205,P16859,P16860,P13204
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Diagnostics Biomarker
|
| Disease from KEGG |
cGMP-PKG signaling pathway, Vascular smooth muscle contraction
|
| Gene Ensembl |
ENSECAG00000014282, ENSMUSG00000029019, ENSCAFG00845001994, ENSG00000120937, ENSBTAG00000021739, ENSMMUG00000055655
|
Pre-made viral vector of BNP/NPPB cDNA Clones/ORF Plasmid
BNP/NPPB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4879 | Pre-made Human NPPB/BNP/Iso-ANP siRNA oligo Duplex | 4879 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25105 | Pre-made Rat Nppb/BNP/Bnf siRNA oligo Duplex | 25105 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18158 | Pre-made Mouse Nppb/BNF/BNP siRNA oligo Duplex | 18158 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715053 | Pre-made Cynomolgus/Rhesus macaque NPPB/NNX siRNA oligo Duplex | 715053 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493764 | Pre-made Cat/Feline NPPB/BNP/Iso-ANP siRNA oligo Duplex | 493764 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487441 | Pre-made Dog/Canine NPPB/BNP/Iso-ANP siRNA oligo Duplex | 487441 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo508734 | Pre-made Bovines/Cattle NPPB/Iso-ANP siRNA oligo Duplex | 508734 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056123 | Pre-made Equine/Horse NPPB siRNA oligo Duplex | 100056123 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BNP/NPPB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T55302-Ab | Human | Anti-Human BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-T55302-Ab | Rat | Anti-Rat BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T55302-Ab | Mouse | Anti-Mouse BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T55302-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-T55302-Ab | Cat/Feline | Anti-Cat/Feline BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T55302-Ab | Dog/Canine | Anti-Dog/Canine BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T55302-Ab | Bovines/Cattle | Anti-Bovines/Cattle BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T55302-Ab | Equine/Horse | Anti-Equine/Horse BNP/NPPB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
BNP/NPPB recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T55302-Ag | Human | Human BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T55302-Ag | Rat | Rat BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T55302-Ag | Mouse | Mouse BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T55302-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T55302-Ag | Cat/Feline | Cat/Feline BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T55302-Ag | Dog/Canine | Dog/Canine BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T55302-Ag | Bovines/Cattle | Bovines/Cattle BNP/NPPB recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T55302-Ag | Equine/Horse | Equine/Horse BNP/NPPB recombinant protein | Mammalian cell | Detail |