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Target
sublocation: Introcelluar Protein.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
Target ID |
GM-T53270
|
Target Name |
ATF4/ATF-4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
468
|
Gene ID |
100070334 (Equus caballus), 101084297 (Felis catus), 11911 (Mus musculus), 468 (Homo sapiens) 474503 (Canis lupus familiaris), 509107 (Bos taurus), 703965 (Macaca mulatta), 79255 (Rattus norvegicus)
|
Target Alternative Names |
ATF4,Atf4,Atf-4,C/ATF,CREB2,CREB-2,TAXREB67,TXREB
|
Uniprot Accession |
Q06507,P18848,Q3ZCH6,Q9ES19
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
Therapeutics Target
|
Disease |
cancer
|
Disease from KEGG |
MAPK signaling pathway, cGMP-PKG signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Cholinergic synapse, Insulin secretion, GnRH signaling pathway, Thyroid hormone synthesis, Aldosterone synthesis and secretion, Relaxin signaling pathway, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Cocaine addiction, Amphetamine addiction, Hepatitis B, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Chemical carcinogenesis - receptor activation, Prostate cancer, Lipid and atherosclerosis
|
Gene Ensembl |
ENSMUSG00000042406, ENSG00000128272, ENSCAFG00845021497, ENSBTAG00000017462, ENSMMUG00000055780
|
Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of ATF4/ATF-4 cDNA Clones/ORF Plasmid
ATF4/ATF-4 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo468 | Pre-made Human ATF4/CREB2/TXREB siRNA oligo Duplex | 468 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo79255 | Pre-made Rat Atf4 siRNA oligo Duplex | 79255 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo11911 | Pre-made Mouse Atf4/Atf-4/C/ATF siRNA oligo Duplex | 11911 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo703965 | Pre-made Cynomolgus/Rhesus macaque ATF4 siRNA oligo Duplex | 703965 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101084297 | Pre-made Cat/Feline ATF4 siRNA oligo Duplex | 101084297 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo474503 | Pre-made Dog/Canine ATF4 siRNA oligo Duplex | 474503 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo509107 | Pre-made Bovines/Cattle ATF4 siRNA oligo Duplex | 509107 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100070334 | Pre-made Equine/Horse ATF4 siRNA oligo Duplex | 100070334 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ATF4/ATF-4 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T53270-Ab | Human | Anti-Human ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-rg-T53270-Ab | Rat | Anti-Rat ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-mg-T53270-Ab | Mouse | Anti-Mouse ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cynog-T53270-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-felg-T53270-Ab | Cat/Feline | Anti-Cat/Feline ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cang-T53270-Ab | Dog/Canine | Anti-Dog/Canine ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-bovg-T53270-Ab | Bovines/Cattle | Anti-Bovines/Cattle ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-equg-T53270-Ab | Equine/Horse | Anti-Equine/Horse ATF4/ATF-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ATF4/ATF-4 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T53270-Ag | Human | Human ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T53270-Ag | Rat | Rat ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T53270-Ag | Mouse | Mouse ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T53270-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T53270-Ag | Cat/Feline | Cat/Feline ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T53270-Ag | Dog/Canine | Dog/Canine ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T53270-Ag | Bovines/Cattle | Bovines/Cattle ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T53270-Ag | Equine/Horse | Equine/Horse ATF4/ATF-4 recombinant protein | Mammalian cell | Detail |