Recombinant multi-species ATF4/ATF-4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATF4/ATF-4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
The Alternative Names of target: ATF4, ATF-4,Cyclic AMP-dependent transcription factor ATF-4,cAMP-dependent transcription factor ATF-4,Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2 (CREB-2, cAMP-responsive element-binding protein 2), Tax-responsive enhancer element-binding protein 67 (TaxREB67),CREB2,TXREB,CREB-2,TAXREB67

Target products collectionGo to ATF4/ATF-4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T53270-Ab-1/ GM-Tg-hg-T53270-Ab-2 Human ATF4/ATF-4 protein Human
GM-Tg-rg-T53270-Ab-1/ GM-Tg-rg-T53270-Ab-2 Rat ATF4/ATF-4 protein Rat
GM-Tg-mg-T53270-Ab-1/ GM-Tg-mg-T53270-Ab-2 Mouse ATF4/ATF-4 protein Mouse
GM-Tg-cynog-T53270-Ab-1/ GM-Tg-cynog-T53270-Ab-2 Cynomolgus/Rhesus macaque ATF4/ATF-4 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T53270-Ab-1/ GM-Tg-felg-T53270-Ab-2 Feline ATF4/ATF-4 protein Feline
GM-Tg-cang-T53270-Ab-1/ GM-Tg-cang-T53270-Ab-2 Canine ATF4/ATF-4 protein Canine
GM-Tg-bovg-T53270-Ab-1/ GM-Tg-bovg-T53270-Ab-2 Bovine ATF4/ATF-4 protein Bovine
GM-Tg-equg-T53270-Ab-1/ GM-Tg-equg-T53270-Ab-2 Equine ATF4/ATF-4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T53270-Ab-1/ GM-Tg-hg-T53270-Ab-2; GM-Tg-rg-T53270-Ab-1/ GM-Tg-rg-T53270-Ab-2;
GM-Tg-mg-T53270-Ab-1/ GM-Tg-mg-T53270-Ab-2; GM-Tg-cynog-T53270-Ab-1/ GM-Tg-cynog-T53270-Ab-2;
GM-Tg-felg-T53270-Ab-1/ GM-Tg-felg-T53270-Ab-2; GM-Tg-cang-T53270-Ab-1/ GM-Tg-cang-T53270-Ab-2;
GM-Tg-bovg-T53270-Ab-1/ GM-Tg-bovg-T53270-Ab-2; GM-Tg-equg-T53270-Ab-1/ GM-Tg-equg-T53270-Ab-2
Products Name ATF4/ATF-4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ATF4/ATF-4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATF4/ATF-4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.