Explore PIM1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
| Target ID |
GM-T50594
|
| Target Name |
PIM1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5292
|
| Gene ID |
100053898 (Equus caballus), 114677751 (Macaca mulatta), 18712 (Mus musculus), 24649 (Rattus norvegicus) 281402 (Bos taurus), 493888 (Felis catus), 5292 (Homo sapiens)
|
| Target Alternative Names |
PIM,PIM1,Pim-1,Pim1,Serine/threonine-protein kinase pim-1,pim-1
|
| Uniprot Accession |
P06803,P26794,Q9N0P9,Q95LJ0,P11309
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
JAK-STAT signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Acute myeloid leukemia
|
| Gene Ensembl |
ENSECAG00000020563, ENSMUSG00000024014, ENSBTAG00000000396, ENSG00000137193
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of PIM1 cDNA Clones/ORF Plasmid
PIM1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5292 | Pre-made Human PIM1/PIM siRNA oligo Duplex | 5292 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24649 | Pre-made Rat Pim1 siRNA oligo Duplex | 24649 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18712 | Pre-made Mouse Pim1/Pim-1 siRNA oligo Duplex | 18712 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114677751 | Pre-made Cynomolgus/Rhesus macaque PIM1 siRNA oligo Duplex | 114677751 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493888 | Pre-made Cat/Feline PIM1/pim-1 siRNA oligo Duplex | 493888 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281402 | Pre-made Bovines/Cattle PIM1 siRNA oligo Duplex | 281402 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053898 | Pre-made Equine/Horse PIM1 siRNA oligo Duplex | 100053898 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PIM1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T50594-Ab | Human | Anti-Human PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T50594-Ab | Rat | Anti-Rat PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T50594-Ab | Mouse | Anti-Mouse PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T50594-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T50594-Ab | Cat/Feline | Anti-Cat/Feline PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T50594-Ab | Bovines/Cattle | Anti-Bovines/Cattle PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T50594-Ab | Equine/Horse | Anti-Equine/Horse PIM1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PIM1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T50594-Ag | Human | Human PIM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T50594-Ag | Rat | Rat PIM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T50594-Ag | Mouse | Mouse PIM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T50594-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PIM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T50594-Ag | Cat/Feline | Cat/Feline PIM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T50594-Ag | Bovines/Cattle | Bovines/Cattle PIM1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T50594-Ag | Equine/Horse | Equine/Horse PIM1 recombinant protein | Mammalian cell | Detail |