Explore RUNX1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T43711
|
| Target Name |
RUNX1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
861
|
| Gene ID |
100051950 (Equus caballus), 101084898 (Felis catus), 12394 (Mus musculus), 487746 (Canis lupus familiaris)
50662 (Rattus norvegicus), 529631 (Bos taurus), 696749 (Macaca mulatta), 861 (Homo sapiens)
|
| Target Alternative Names |
AML1,AML1-EVI-1,AMLCR1,Acute myeloid leukemia 1 protein,Aml1,CBF-alpha-2,CBF2alpha,CBFA2,Cbfa2,Core-binding factor subunit alpha-2 (CBF-alpha-2),EVI-1,Oncogene AML-1,PEA2-alpha,PEBP2-alpha,PEBP2-alpha B),PEBP2aB,PEBP2alpha,Pebp2a2,Pebpa2b,Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B,RUNX1,Runt-related transcription factor 1,Runx1,SL3-3 enhancer factor 1 alpha B subunit,SL3/AKV core-binding factor alpha B subunit
|
| Uniprot Accession |
Q03347,Q63046,Q01196
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Tight junction, Th17 cell differentiation, Pathways in cancer, Chronic myeloid leukemia, Acute myeloid leukemia
|
| Gene Ensembl |
ENSECAG00000003462, ENSMUSG00000022952, ENSCAFG00845026139, ENSBTAG00000004742, ENSMMUG00000001649, ENSG00000159216
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of RUNX1 cDNA Clones/ORF Plasmid
RUNX1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo861 | Pre-made Human RUNX1/AML1/CBFA2 siRNA oligo Duplex | 861 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50662 | Pre-made Rat Runx1/Aml1/Cbfa2 siRNA oligo Duplex | 50662 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12394 | Pre-made Mouse Runx1/AML1/Cbfa2 siRNA oligo Duplex | 12394 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696749 | Pre-made Cynomolgus/Rhesus macaque RUNX1 siRNA oligo Duplex | 696749 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084898 | Pre-made Cat/Feline RUNX1 siRNA oligo Duplex | 101084898 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487746 | Pre-made Dog/Canine RUNX1 siRNA oligo Duplex | 487746 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo529631 | Pre-made Bovines/Cattle RUNX1 siRNA oligo Duplex | 529631 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051950 | Pre-made Equine/Horse RUNX1 siRNA oligo Duplex | 100051950 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RUNX1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43711-Ab | Human | Anti-Human RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T43711-Ab | Rat | Anti-Rat RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T43711-Ab | Mouse | Anti-Mouse RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T43711-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T43711-Ab | Cat/Feline | Anti-Cat/Feline RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T43711-Ab | Dog/Canine | Anti-Dog/Canine RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T43711-Ab | Bovines/Cattle | Anti-Bovines/Cattle RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T43711-Ab | Equine/Horse | Anti-Equine/Horse RUNX1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
RUNX1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43711-Ag | Human | Human RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T43711-Ag | Rat | Rat RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T43711-Ag | Mouse | Mouse RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T43711-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T43711-Ag | Cat/Feline | Cat/Feline RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T43711-Ag | Dog/Canine | Dog/Canine RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T43711-Ag | Bovines/Cattle | Bovines/Cattle RUNX1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T43711-Ag | Equine/Horse | Equine/Horse RUNX1 recombinant protein | Mammalian cell | Detail |
