Recombinant multi-species RUNX1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RUNX1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: AML1,AML1-EVI-1,AMLCR1,Acute myeloid leukemia 1 protein,Aml1,CBF-alpha-2,CBF2alpha,CBFA2,Cbfa2,Core-binding factor subunit alpha-2 (CBF-alpha-2),EVI-1,Oncogene AML-1,PEA2-alpha,PEBP2-alpha,PEBP2-alpha B),PEBP2aB,PEBP2alpha,Pebp2a2,Pebpa2b,Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B,RUNX1,Runt-related transcription factor 1,Runx1,SL3-3 enhancer factor 1 alpha B subunit,SL3/AKV core-binding factor alpha B subunit

Target products collectionGo to RUNX1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T43711-Ag-1/ GM-Tg-hg-T43711-Ag-2 Human RUNX1 protein Human
GM-Tg-rg-T43711-Ag-1/ GM-Tg-rg-T43711-Ag-2 Rat RUNX1 protein Rat
GM-Tg-mg-T43711-Ag-1/ GM-Tg-mg-T43711-Ag-2 Mouse RUNX1 protein Mouse
GM-Tg-cynog-T43711-Ag-1/ GM-Tg-cynog-T43711-Ag-2 Cynomolgus/Rhesus macaque RUNX1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T43711-Ag-1/ GM-Tg-felg-T43711-Ag-2 Feline RUNX1 protein Feline
GM-Tg-cang-T43711-Ag-1/ GM-Tg-cang-T43711-Ag-2 Canine RUNX1 protein Canine
GM-Tg-bovg-T43711-Ag-1/ GM-Tg-bovg-T43711-Ag-2 Bovine RUNX1 protein Bovine
GM-Tg-equg-T43711-Ag-1/ GM-Tg-equg-T43711-Ag-2 Equine RUNX1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T43711-Ag-1/ GM-Tg-hg-T43711-Ag-2; GM-Tg-rg-T43711-Ag-1/ GM-Tg-rg-T43711-Ag-2;
GM-Tg-mg-T43711-Ag-1/ GM-Tg-mg-T43711-Ag-2; GM-Tg-cynog-T43711-Ag-1/ GM-Tg-cynog-T43711-Ag-2;
GM-Tg-felg-T43711-Ag-1/ GM-Tg-felg-T43711-Ag-2; GM-Tg-cang-T43711-Ag-1/ GM-Tg-cang-T43711-Ag-2;
GM-Tg-bovg-T43711-Ag-1/ GM-Tg-bovg-T43711-Ag-2; GM-Tg-equg-T43711-Ag-1/ GM-Tg-equg-T43711-Ag-2
Products Name RUNX1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RUNX1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RUNX1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.