Explore AGR2/AG-2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Target ID |
GM-T34352
|
Target Name |
AGR2/AG-2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
10551
|
Gene ID |
100053075 (Equus caballus), 101084694 (Felis catus), 10551 (Homo sapiens), 23795 (Mus musculus) 298961 (Rattus norvegicus), 415112 (Bos taurus), 482333 (Canis lupus familiaris), 709127 (Macaca mulatta)
|
Target Alternative Names |
AG-2,AG2,AGR2,Agr2,Agr2h,Anterior gradient protein 2 homolog,GOB-4,Gob-4,HAG-2,HEL-S-116,HPC8,PDIA17,RIFTD,Secreted cement gland protein XAG-2 homolog,XAG-2,hAG-2,mAG-2
|
Uniprot Accession |
O95994,O88312
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target
|
Disease |
cancer, Prostate Cancer, Malignant neoplasm of prostate
|
Disease from KEGG |
|
Gene Ensembl |
ENSECAG00000043283, ENSG00000106541, ENSMUSG00000020581, ENSBTAG00000024406, ENSCAFG00845005787, ENSMMUG00000017050
|
Target Classification |
|
Pre-made viral vector of AGR2/AG-2 cDNA Clones/ORF Plasmid
AGR2/AG-2 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo10551 | Pre-made Human AGR2/AG2/AG-2 siRNA oligo Duplex | 10551 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo298961 | Pre-made Rat Agr2 siRNA oligo Duplex | 298961 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo23795 | Pre-made Mouse Agr2/Agr2h/Gob-4 siRNA oligo Duplex | 23795 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo709127 | Pre-made Cynomolgus/Rhesus macaque AGR2 siRNA oligo Duplex | 709127 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101084694 | Pre-made Cat/Feline AGR2 siRNA oligo Duplex | 101084694 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo482333 | Pre-made Dog/Canine AGR2 siRNA oligo Duplex | 482333 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo415112 | Pre-made Bovines/Cattle AGR2 siRNA oligo Duplex | 415112 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100053075 | Pre-made Equine/Horse AGR2 siRNA oligo Duplex | 100053075 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AGR2/AG-2 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T34352-Ab | Human | Anti-Human AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T34352-Ab | Rat | Anti-Rat AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T34352-Ab | Mouse | Anti-Mouse AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T34352-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T34352-Ab | Cat/Feline | Anti-Cat/Feline AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T34352-Ab | Dog/Canine | Anti-Dog/Canine AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T34352-Ab | Bovines/Cattle | Anti-Bovines/Cattle AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T34352-Ab | Equine/Horse | Anti-Equine/Horse AGR2/AG-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
AGR2/AG-2 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T34352-Ag | Human | Human AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T34352-Ag | Rat | Rat AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T34352-Ag | Mouse | Mouse AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T34352-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T34352-Ag | Cat/Feline | Cat/Feline AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T34352-Ag | Dog/Canine | Dog/Canine AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T34352-Ag | Bovines/Cattle | Bovines/Cattle AGR2/AG-2 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T34352-Ag | Equine/Horse | Equine/Horse AGR2/AG-2 recombinant protein | Mammalian cell | Detail |