Explore HAMP gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Secreted Protein/Potential Cytokines.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
Target ID |
GM-T22995
|
Target Name |
HAMP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
57817
|
Gene ID |
100050728 (Equus caballus), 101084332 (Felis catus), 492281 (Canis lupus familiaris), 512301 (Bos taurus) 57817 (Homo sapiens), 708397 (Macaca mulatta), 84506 (Mus musculus), 84604 (Rattus norvegicus)
|
Target Alternative Names |
HAMP,Hamp,hepcidin,HEPC,PLTR,HFE2B,LEAP1,Hepc,Hamp1,Hepc1
|
Uniprot Accession |
Q5U9D2,P81172,Q9EQ21,Q99MH3
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target
|
Disease |
Ovary Cancer
|
Disease from KEGG |
TGF-beta signaling pathway
|
Gene Ensembl |
ENSCAFG00845003240, ENSBTAG00000017042, ENSG00000105697, ENSMMUG00000011288, ENSMUSG00000050440
|
Target Classification |
|
Pre-made viral vector of HAMP cDNA Clones/ORF Plasmid
HAMP siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo57817 | Pre-made Human HAMP/HEPC/PLTR siRNA oligo Duplex | 57817 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo84604 | Pre-made Rat Hamp/Hepc siRNA oligo Duplex | 84604 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo84506 | Pre-made Mouse Hamp/Hepc/Hamp1 siRNA oligo Duplex | 84506 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo708397 | Pre-made Cynomolgus/Rhesus macaque HAMP siRNA oligo Duplex | 708397 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101084332 | Pre-made Cat/Feline HAMP siRNA oligo Duplex | 101084332 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo492281 | Pre-made Dog/Canine HAMP siRNA oligo Duplex | 492281 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo512301 | Pre-made Bovines/Cattle HAMP/hepcidin siRNA oligo Duplex | 512301 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100050728 | Pre-made Equine/Horse HAMP siRNA oligo Duplex | 100050728 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HAMP antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T22995-Ab | Human | Anti-Human HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T22995-Ab | Rat | Anti-Rat HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T22995-Ab | Mouse | Anti-Mouse HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T22995-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T22995-Ab | Cat/Feline | Anti-Cat/Feline HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T22995-Ab | Dog/Canine | Anti-Dog/Canine HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T22995-Ab | Bovines/Cattle | Anti-Bovines/Cattle HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T22995-Ab | Equine/Horse | Anti-Equine/Horse HAMP monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HAMP recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T22995-Ag | Human | Human HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T22995-Ag | Rat | Rat HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T22995-Ag | Mouse | Mouse HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T22995-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T22995-Ag | Cat/Feline | Cat/Feline HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T22995-Ag | Dog/Canine | Dog/Canine HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T22995-Ag | Bovines/Cattle | Bovines/Cattle HAMP recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T22995-Ag | Equine/Horse | Equine/Horse HAMP recombinant protein | Mammalian cell | Detail |