Recombinant multi-species HAMP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HAMP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
The Alternative Names of target: HAMP,Hepcidin,Liver-expressed antimicrobial peptide 1 (LEAP-1), Putative liver tumor regressor (PLTR),HEPC,PLTR,HFE2B,LEAP1

Target products collectionGo to HAMP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T22995-Ab-1/ GM-Tg-hg-T22995-Ab-2 Human HAMP protein Human
GM-Tg-rg-T22995-Ab-1/ GM-Tg-rg-T22995-Ab-2 Rat HAMP protein Rat
GM-Tg-mg-T22995-Ab-1/ GM-Tg-mg-T22995-Ab-2 Mouse HAMP protein Mouse
GM-Tg-cynog-T22995-Ab-1/ GM-Tg-cynog-T22995-Ab-2 Cynomolgus/Rhesus macaque HAMP monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T22995-Ab-1/ GM-Tg-felg-T22995-Ab-2 Feline HAMP protein Feline
GM-Tg-cang-T22995-Ab-1/ GM-Tg-cang-T22995-Ab-2 Canine HAMP protein Canine
GM-Tg-bovg-T22995-Ab-1/ GM-Tg-bovg-T22995-Ab-2 Bovine HAMP protein Bovine
GM-Tg-equg-T22995-Ab-1/ GM-Tg-equg-T22995-Ab-2 Equine HAMP protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T22995-Ab-1/ GM-Tg-hg-T22995-Ab-2; GM-Tg-rg-T22995-Ab-1/ GM-Tg-rg-T22995-Ab-2;
GM-Tg-mg-T22995-Ab-1/ GM-Tg-mg-T22995-Ab-2; GM-Tg-cynog-T22995-Ab-1/ GM-Tg-cynog-T22995-Ab-2;
GM-Tg-felg-T22995-Ab-1/ GM-Tg-felg-T22995-Ab-2; GM-Tg-cang-T22995-Ab-1/ GM-Tg-cang-T22995-Ab-2;
GM-Tg-bovg-T22995-Ab-1/ GM-Tg-bovg-T22995-Ab-2; GM-Tg-equg-T22995-Ab-1/ GM-Tg-equg-T22995-Ab-2
Products Name HAMP protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HAMP
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HAMP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.