CXCL8/IL-8/IL8 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore CXCL8/IL-8/IL8 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]

Target ID GM-T22658
Target Name CXCL8/IL-8/IL8
Gene Group ldentifer
(Target Gene ID in Homo species)
3576
Gene ID 100037400 (Equus caballus), 280828 (Bos taurus), 3576 (Homo sapiens), 403850 (Canis lupus familiaris)
613028 (Macaca mulatta)
Target Alternative Names C-X-C motif chemokine 8,CXCL8,Chemokine (C-X-C motif) ligand 8,Emoctakin,GCP-1,GCP1,Granulocyte chemotactic protein 1 (GCP-1),IL-8,IL8,Interleukin-8,LECT,LUCT,LYNAP,MDNCF,MONAP,Monocyte-derived neutrophil chemotactic factor (MDNCF),Monocyte-derived neutrophil-activating peptide (MONAP),NAF,NAP-1,NAP1,Neutrophil-activating protein 1 (NAP-1),Protein 3-10C,SCYB8,T-cell chemotactic factor
Uniprot Accession O62812,P79255,P10145,P41324,P67813
Uniprot Entry Name
Protein Sub-location Secreted Protein/Potential Cytokines
Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
Disease
Disease from KEGG Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NF-kappa B signaling pathway, Phospholipase D signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease, Malaria, Amoebiasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Bladder cancer, Rheumatoid arthritis, Lipid and atherosclerosis
Gene Ensembl ENSECAG00000015342, ENSBTAG00000019716, ENSG00000169429, ENSMMUG00000060156
Target Classification Checkpoint-Immuno Oncology


Pre-made viral vector of CXCL8/IL-8/IL8 cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLV000447Human CXCL8/GCP-1/GCP1 Lentivirus plasmidNM_000584.33576HumanLentivirus plasmidmcherry-Firefly luciferase3xflag (C-Terminal)CMVDetail
pGMLV000943Human CXCL8/GCP-1/GCP1 Lentivirus plasmidNM_000584.43576HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV001490Human CXCL8/GCP-1/GCP1 Lentivirus plasmidNM_000584.43576HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMAD000710Human CXCL8/GCP-1/GCP1 Adenovirus plasmidNM_0005843576HumanAdenovirus plasmidNull3xflag (C-Terminal)CMVDetail
pGMAP000556Human IL8/3-10C/AMCF-I Adenovirus plasmidBC0136153576HumanAdenovirus plasmidGFP3xflag (C-Terminal)EF1Detail
pGMLP-IL-011Human CXCL8/GCP-1/GCP1 Lentivirus plasmidNM_0005843576HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMAP-IL-094Human CXCL8/GCP-1/GCP1 Adenovirus plasmidNM_0005843576HumanAdenovirus plasmidEGFP3xflag (C-Terminal)EF1Detail
vGMLV000447Human CXCL8/GCP-1/GCP1 Lentivirus particleNM_000584.33576HumanLentivirus particlemcherry-Firefly luciferase3xflag (C-Terminal)CMVDetail
vGMLV000943Human CXCL8/GCP-1/GCP1 Lentivirus particleNM_000584.43576HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV001490Human CXCL8/GCP-1/GCP1 Lentivirus particleNM_000584.43576HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMAD000710Human CXCL8/GCP-1/GCP1 Adenovirus particleNM_0005843576HumanAdenovirus particleNull3xflag (C-Terminal)CMVDetail
vGMAP000556Human IL8/3-10C/AMCF-I Adenovirus particleBC0136153576HumanAdenovirus particleGFP3xflag (C-Terminal)EF1Detail
vGMLP-IL-011Human CXCL8/GCP-1/GCP1 Lentivirus particleNM_0005843576HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMAP-IL-094Human CXCL8/GCP-1/GCP1 Adenovirus particleNM_0005843576HumanAdenovirus particleEGFP3xflag (C-Terminal)EF1Detail


CXCL8/IL-8/IL8 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo3576Pre-made Human CXCL8/IL8/NAF siRNA oligo Duplex3576HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo613028Pre-made Cynomolgus/Rhesus macaque CXCL8/IL8 siRNA oligo Duplex613028Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo403850Pre-made Dog/Canine CXCL8/IL8 siRNA oligo Duplex403850Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo280828Pre-made Bovines/Cattle CXCL8/IL8/IL-8 siRNA oligo Duplex280828Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100037400Pre-made Equine/Horse CXCL8/IL8 siRNA oligo Duplex100037400Equine/HorseIn-vitro grade; in-vivo gradeDetail


CXCL8/IL-8/IL8 antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T22658-AbHumanAnti-Human CXCL8/IL-8/IL8 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cynog-T22658-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque CXCL8/IL-8/IL8 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cang-T22658-AbDog/CanineAnti-Dog/Canine CXCL8/IL-8/IL8 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-bovg-T22658-AbBovines/CattleAnti-Bovines/Cattle CXCL8/IL-8/IL8 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-equg-T22658-AbEquine/HorseAnti-Equine/Horse CXCL8/IL-8/IL8 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail


CXCL8/IL-8/IL8 recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T22658-AgHumanHuman CXCL8/IL-8/IL8 recombinant proteinMammalian cellDetail
GM-Tg-cynog-T22658-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque CXCL8/IL-8/IL8 recombinant proteinMammalian cellDetail
GM-Tg-cang-T22658-AgDog/CanineDog/Canine CXCL8/IL-8/IL8 recombinant proteinMammalian cellDetail
GM-Tg-bovg-T22658-AgBovines/CattleBovines/Cattle CXCL8/IL-8/IL8 recombinant proteinMammalian cellDetail
GM-Tg-equg-T22658-AgEquine/HorseEquine/Horse CXCL8/IL-8/IL8 recombinant proteinMammalian cellDetail