Explore CXCL8/IL-8/IL8 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]
Target ID |
GM-T22658
|
Target Name |
CXCL8/IL-8/IL8
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3576
|
Gene ID |
100037400 (Equus caballus), 280828 (Bos taurus), 3576 (Homo sapiens), 403850 (Canis lupus familiaris) 613028 (Macaca mulatta)
|
Target Alternative Names |
C-X-C motif chemokine 8,CXCL8,Chemokine (C-X-C motif) ligand 8,Emoctakin,GCP-1,GCP1,Granulocyte chemotactic protein 1 (GCP-1),IL-8,IL8,Interleukin-8,LECT,LUCT,LYNAP,MDNCF,MONAP,Monocyte-derived neutrophil chemotactic factor (MDNCF),Monocyte-derived neutrophil-activating peptide (MONAP),NAF,NAP-1,NAP1,Neutrophil-activating protein 1 (NAP-1),Protein 3-10C,SCYB8,T-cell chemotactic factor
|
Uniprot Accession |
O62812,P79255,P10145,P41324,P67813
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
Disease |
|
Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NF-kappa B signaling pathway, Phospholipase D signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease, Malaria, Amoebiasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Bladder cancer, Rheumatoid arthritis, Lipid and atherosclerosis
|
Gene Ensembl |
ENSECAG00000015342, ENSBTAG00000019716, ENSG00000169429, ENSMMUG00000060156
|
Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CXCL8/IL-8/IL8 cDNA Clones/ORF Plasmid
CXCL8/IL-8/IL8 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo3576 | Pre-made Human CXCL8/IL8/NAF siRNA oligo Duplex | 3576 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo613028 | Pre-made Cynomolgus/Rhesus macaque CXCL8/IL8 siRNA oligo Duplex | 613028 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo403850 | Pre-made Dog/Canine CXCL8/IL8 siRNA oligo Duplex | 403850 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo280828 | Pre-made Bovines/Cattle CXCL8/IL8/IL-8 siRNA oligo Duplex | 280828 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100037400 | Pre-made Equine/Horse CXCL8/IL8 siRNA oligo Duplex | 100037400 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CXCL8/IL-8/IL8 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T22658-Ab | Human | Anti-Human CXCL8/IL-8/IL8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T22658-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CXCL8/IL-8/IL8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T22658-Ab | Dog/Canine | Anti-Dog/Canine CXCL8/IL-8/IL8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T22658-Ab | Bovines/Cattle | Anti-Bovines/Cattle CXCL8/IL-8/IL8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T22658-Ab | Equine/Horse | Anti-Equine/Horse CXCL8/IL-8/IL8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CXCL8/IL-8/IL8 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T22658-Ag | Human | Human CXCL8/IL-8/IL8 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T22658-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CXCL8/IL-8/IL8 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T22658-Ag | Dog/Canine | Dog/Canine CXCL8/IL-8/IL8 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T22658-Ag | Bovines/Cattle | Bovines/Cattle CXCL8/IL-8/IL8 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T22658-Ag | Equine/Horse | Equine/Horse CXCL8/IL-8/IL8 recombinant protein | Mammalian cell | Detail |