Recombinant multi-species CXCL8/IL-8/IL8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CXCL8/IL-8/IL8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]
The Alternative Names of target: C-X-C motif chemokine 8,CXCL8,Chemokine (C-X-C motif) ligand 8,Emoctakin,GCP-1,GCP1,Granulocyte chemotactic protein 1 (GCP-1),IL-8,IL8,Interleukin-8,LECT,LUCT,LYNAP,MDNCF,MONAP,Monocyte-derived neutrophil chemotactic factor (MDNCF),Monocyte-derived neutrophil-activating peptide (MONAP),NAF,NAP-1,NAP1,Neutrophil-activating protein 1 (NAP-1),Protein 3-10C,SCYB8,T-cell chemotactic factor

Target products collectionGo to CXCL8/IL-8/IL8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T22658-Ag-1/ GM-Tg-hg-T22658-Ag-2 Human CXCL8/IL-8/IL8 protein Human
GM-Tg-rg-T22658-Ag-1/ GM-Tg-rg-T22658-Ag-2 Rat CXCL8/IL-8/IL8 protein Rat
GM-Tg-mg-T22658-Ag-1/ GM-Tg-mg-T22658-Ag-2 Mouse CXCL8/IL-8/IL8 protein Mouse
GM-Tg-cynog-T22658-Ag-1/ GM-Tg-cynog-T22658-Ag-2 Cynomolgus/Rhesus macaque CXCL8/IL-8/IL8 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T22658-Ag-1/ GM-Tg-felg-T22658-Ag-2 Feline CXCL8/IL-8/IL8 protein Feline
GM-Tg-cang-T22658-Ag-1/ GM-Tg-cang-T22658-Ag-2 Canine CXCL8/IL-8/IL8 protein Canine
GM-Tg-bovg-T22658-Ag-1/ GM-Tg-bovg-T22658-Ag-2 Bovine CXCL8/IL-8/IL8 protein Bovine
GM-Tg-equg-T22658-Ag-1/ GM-Tg-equg-T22658-Ag-2 Equine CXCL8/IL-8/IL8 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T22658-Ag-1/ GM-Tg-hg-T22658-Ag-2; GM-Tg-rg-T22658-Ag-1/ GM-Tg-rg-T22658-Ag-2;
GM-Tg-mg-T22658-Ag-1/ GM-Tg-mg-T22658-Ag-2; GM-Tg-cynog-T22658-Ag-1/ GM-Tg-cynog-T22658-Ag-2;
GM-Tg-felg-T22658-Ag-1/ GM-Tg-felg-T22658-Ag-2; GM-Tg-cang-T22658-Ag-1/ GM-Tg-cang-T22658-Ag-2;
GM-Tg-bovg-T22658-Ag-1/ GM-Tg-bovg-T22658-Ag-2; GM-Tg-equg-T22658-Ag-1/ GM-Tg-equg-T22658-Ag-2
Products Name CXCL8/IL-8/IL8 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CXCL8/IL-8/IL8
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CXCL8/IL-8/IL8 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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