Explore RANTES/CCL5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
| Target ID |
GM-T16263
|
| Target Name |
RANTES/CCL5
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6352
|
| Gene ID |
100033925 (Equus caballus), 20304 (Mus musculus), 327712 (Bos taurus), 403522 (Canis lupus familiaris) 493689 (Felis catus), 574178 (Macaca mulatta), 6352 (Homo sapiens), 81780 (Rattus norvegicus)
|
| Target Alternative Names |
C-C motif chemokine 5,CCL5,Ccl5,D17S136E,EoCP,Eosinophil chemotactic cytokine,MuRantes,RANTES,Rantes,SCYA5,SIS-delta,SISd,Scya5,Small-inducible cytokine A5,T cell-specific protein P228 (TCP228),T-cell-specific protein RANTES,TCP228,eoCP
|
| Uniprot Accession |
Q8MKD0,P30882,O97919,Q8HYS0,Q8SQ40,Q8HYQ1,P13501,P50231
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer, Breast Cancer, Type 1 diabetes mellitus, Chronic Kidney Disease
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, TNF signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Chagas disease, Human cytomegalovirus infection, Influenza A, Rheumatoid arthritis, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSMUSG00000035042, ENSBTAG00000066072, ENSMMUG00000054796, ENSG00000271503
|
Pre-made viral vector of RANTES/CCL5 cDNA Clones/ORF Plasmid
RANTES/CCL5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6352 | Pre-made Human CCL5/SISd/eoCP siRNA oligo Duplex | 6352 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81780 | Pre-made Rat Ccl5/Scya5/Rantes siRNA oligo Duplex | 81780 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20304 | Pre-made Mouse Ccl5/SISd/Scya5 siRNA oligo Duplex | 20304 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574178 | Pre-made Cynomolgus/Rhesus macaque CCL5 siRNA oligo Duplex | 574178 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493689 | Pre-made Cat/Feline CCL5/RANTES siRNA oligo Duplex | 493689 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403522 | Pre-made Dog/Canine CCL5/RANTES siRNA oligo Duplex | 403522 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo327712 | Pre-made Bovines/Cattle CCL5/RANTES siRNA oligo Duplex | 327712 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033925 | Pre-made Equine/Horse CCL5/SCYA5/RANTES siRNA oligo Duplex | 100033925 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RANTES/CCL5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T16263-Ab | Human | Anti-Human RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T16263-Ab | Rat | Anti-Rat RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T16263-Ab | Mouse | Anti-Mouse RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T16263-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T16263-Ab | Cat/Feline | Anti-Cat/Feline RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T16263-Ab | Dog/Canine | Anti-Dog/Canine RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T16263-Ab | Bovines/Cattle | Anti-Bovines/Cattle RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T16263-Ab | Equine/Horse | Anti-Equine/Horse RANTES/CCL5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
RANTES/CCL5 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T16263-Ag | Human | Human RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T16263-Ag | Rat | Rat RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T16263-Ag | Mouse | Mouse RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T16263-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T16263-Ag | Cat/Feline | Cat/Feline RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T16263-Ag | Dog/Canine | Dog/Canine RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T16263-Ag | Bovines/Cattle | Bovines/Cattle RANTES/CCL5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T16263-Ag | Equine/Horse | Equine/Horse RANTES/CCL5 recombinant protein | Mammalian cell | Detail |