Explore IL-10/IL10 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
| Target ID |
GM-T09092
|
| Target Name |
IL-10/IL10
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3586
|
| Gene ID |
100034187 (Equus caballus), 16153 (Mus musculus), 25325 (Rattus norvegicus), 281246 (Bos taurus)
3586 (Homo sapiens), 403628 (Canis lupus familiaris), 493683 (Felis catus), 694931 (Macaca mulatta)
|
| Target Alternative Names |
CSIF,Cytokine synthesis inhibitory factor (CSIF),GVHDS,IF2A,IL-10,IL10,IL10A,IL10X,If2a,Il-10,Il10,Interleukin-10,TGIF
|
| Uniprot Accession |
Q28374,P18893,P29456,P43480,P22301,P48411,P55029,P51496
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease |
cancer, Ovary Cancer, metastases, asthma, Malignant neoplasm of bladder
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, FoxO signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, Intestinal immune network for IgA production, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Allograft rejection
|
| Gene Ensembl |
ENSMUSG00000016529, ENSBTAG00000006685, ENSG00000136634, ENSCAFG00845001289, ENSMMUG00000023569
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of IL-10/IL10 cDNA Clones/ORF Plasmid
IL-10/IL10 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3586 | Pre-made Human IL10/CSIF/TGIF siRNA oligo Duplex | 3586 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25325 | Pre-made Rat Il10/If2a/IL10X siRNA oligo Duplex | 25325 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16153 | Pre-made Mouse Il10/CSIF/If2a siRNA oligo Duplex | 16153 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694931 | Pre-made Cynomolgus/Rhesus macaque IL10 siRNA oligo Duplex | 694931 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493683 | Pre-made Cat/Feline IL10 siRNA oligo Duplex | 493683 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403628 | Pre-made Dog/Canine IL10/IL-10 siRNA oligo Duplex | 403628 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281246 | Pre-made Bovines/Cattle IL10/IF2A siRNA oligo Duplex | 281246 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034187 | Pre-made Equine/Horse IL10/IF2A/IL-10 siRNA oligo Duplex | 100034187 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-10/IL10 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T09092-Ab | Human | Anti-Human IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T09092-Ab | Rat | Anti-Rat IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T09092-Ab | Mouse | Anti-Mouse IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T09092-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T09092-Ab | Cat/Feline | Anti-Cat/Feline IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T09092-Ab | Dog/Canine | Anti-Dog/Canine IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T09092-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T09092-Ab | Equine/Horse | Anti-Equine/Horse IL-10/IL10 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IL-10/IL10 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T09092-Ag | Human | Human IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T09092-Ag | Rat | Rat IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T09092-Ag | Mouse | Mouse IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T09092-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T09092-Ag | Cat/Feline | Cat/Feline IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T09092-Ag | Dog/Canine | Dog/Canine IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T09092-Ag | Bovines/Cattle | Bovines/Cattle IL-10/IL10 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T09092-Ag | Equine/Horse | Equine/Horse IL-10/IL10 recombinant protein | Mammalian cell | Detail |
