Recombinant multi-species IL-10/IL10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-10/IL10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
The Alternative Names of target: CSIF,Cytokine synthesis inhibitory factor (CSIF),GVHDS,IF2A,IL-10,IL10,IL10A,IL10X,If2a,Il-10,Il10,Interleukin-10,TGIF

Target products collectionGo to IL-10/IL10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T09092-Ag-1/ GM-Tg-hg-T09092-Ag-2 Human IL-10/IL10 protein Human
GM-Tg-rg-T09092-Ag-1/ GM-Tg-rg-T09092-Ag-2 Rat IL-10/IL10 protein Rat
GM-Tg-mg-T09092-Ag-1/ GM-Tg-mg-T09092-Ag-2 Mouse IL-10/IL10 protein Mouse
GM-Tg-cynog-T09092-Ag-1/ GM-Tg-cynog-T09092-Ag-2 Cynomolgus/Rhesus macaque IL-10/IL10 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T09092-Ag-1/ GM-Tg-felg-T09092-Ag-2 Feline IL-10/IL10 protein Feline
GM-Tg-cang-T09092-Ag-1/ GM-Tg-cang-T09092-Ag-2 Canine IL-10/IL10 protein Canine
GM-Tg-bovg-T09092-Ag-1/ GM-Tg-bovg-T09092-Ag-2 Bovine IL-10/IL10 protein Bovine
GM-Tg-equg-T09092-Ag-1/ GM-Tg-equg-T09092-Ag-2 Equine IL-10/IL10 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T09092-Ag-1/ GM-Tg-hg-T09092-Ag-2; GM-Tg-rg-T09092-Ag-1/ GM-Tg-rg-T09092-Ag-2;
GM-Tg-mg-T09092-Ag-1/ GM-Tg-mg-T09092-Ag-2; GM-Tg-cynog-T09092-Ag-1/ GM-Tg-cynog-T09092-Ag-2;
GM-Tg-felg-T09092-Ag-1/ GM-Tg-felg-T09092-Ag-2; GM-Tg-cang-T09092-Ag-1/ GM-Tg-cang-T09092-Ag-2;
GM-Tg-bovg-T09092-Ag-1/ GM-Tg-bovg-T09092-Ag-2; GM-Tg-equg-T09092-Ag-1/ GM-Tg-equg-T09092-Ag-2
Products Name IL-10/IL10 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-10/IL10
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-10/IL10 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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