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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T07958
|
| Target Name |
EPO/Erythropoietin
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2056
|
| Gene ID |
100033849 (Equus caballus), 13856 (Mus musculus), 2056 (Homo sapiens), 24335 (Rattus norvegicus) 280784 (Bos taurus), 404002 (Canis lupus familiaris), 493801 (Felis catus), 719294 (Macaca mulatta)
|
| Target Alternative Names |
DBAL,ECYT5,EP,EPO,Epo,Erythropoietin,MVCD2
|
| Uniprot Accession |
Q867B1,P07321,P01588,P29676,P48617,P33707,P33708,Q28513
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Diagnostics Biomarker
|
| Disease |
Asthma, prolonged cough, lung function assessment, Eosinophilic airway inflammation, breast cancer, Sepsis
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000010733, ENSMUSG00000029711, ENSG00000130427, ENSBTAG00000003430, ENSCAFG00845001075, ENSMMUG00000022863
|
Pre-made viral vector of EPO/Erythropoietin cDNA Clones/ORF Plasmid
EPO/Erythropoietin siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2056 | Pre-made Human EPO/EP/DBAL siRNA oligo Duplex | 2056 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24335 | Pre-made Rat Epo siRNA oligo Duplex | 24335 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13856 | Pre-made Mouse Epo siRNA oligo Duplex | 13856 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719294 | Pre-made Cynomolgus/Rhesus macaque EPO siRNA oligo Duplex | 719294 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493801 | Pre-made Cat/Feline EPO siRNA oligo Duplex | 493801 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404002 | Pre-made Dog/Canine EPO siRNA oligo Duplex | 404002 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280784 | Pre-made Bovines/Cattle EPO siRNA oligo Duplex | 280784 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100033849 | Pre-made Equine/Horse EPO siRNA oligo Duplex | 100033849 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EPO/Erythropoietin antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T07958-Ab | Human | Anti-Human EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-rg-T07958-Ab | Rat | Anti-Rat EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-mg-T07958-Ab | Mouse | Anti-Mouse EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cynog-T07958-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-felg-T07958-Ab | Cat/Feline | Anti-Cat/Feline EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-cang-T07958-Ab | Dog/Canine | Anti-Dog/Canine EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-bovg-T07958-Ab | Bovines/Cattle | Anti-Bovines/Cattle EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
| GM-Tg-equg-T07958-Ab | Equine/Horse | Anti-Equine/Horse EPO/Erythropoietin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody | Detail |
EPO/Erythropoietin recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T07958-Ag | Human | Human EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T07958-Ag | Rat | Rat EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T07958-Ag | Mouse | Mouse EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T07958-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T07958-Ag | Cat/Feline | Cat/Feline EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T07958-Ag | Dog/Canine | Dog/Canine EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T07958-Ag | Bovines/Cattle | Bovines/Cattle EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T07958-Ag | Equine/Horse | Equine/Horse EPO/Erythropoietin recombinant protein | Mammalian cell | Detail |