Explore IL-18/IL18 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
Target ID |
GM-T06671
|
Target Name |
IL-18/IL18
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3606
|
Gene ID |
100034216 (Equus caballus), 16173 (Mus musculus), 281249 (Bos taurus), 29197 (Rattus norvegicus) 3606 (Homo sapiens), 403796 (Canis lupus familiaris), 493688 (Felis catus), 574151 (Macaca mulatta)
|
Target Alternative Names |
IL18,Il18,IGIF,IL-18,Igif,Il-18,IL-1 gamma,IL-1g,IL1F4
|
Uniprot Accession |
Q9XSQ7,P70380,Q9TU73,P97636,Q14116,Q9XSR0,Q95M33
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target, Cytokine Target
|
Disease |
cancer, Breast Cancer, Acute kidney failure, Overweight
|
Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NOD-like receptor signaling pathway, Pathogenic Escherichia coli infection, Legionellosis, Yersinia infection, African trypanosomiasis, Malaria, Tuberculosis, Influenza A, Inflammatory bowel disease, Rheumatoid arthritis, Lipid and atherosclerosis
|
Gene Ensembl |
ENSECAG00000015261, ENSMUSG00000039217, ENSBTAG00000000277, ENSG00000150782, ENSCAFG00845001557, ENSMMUG00000064111
|
Target Classification |
Cytokine Receptor
|
Pre-made viral vector of IL-18/IL18 cDNA Clones/ORF Plasmid
IL-18/IL18 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo3606 | Pre-made Human IL18/IGIF/IL-18 siRNA oligo Duplex | 3606 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo29197 | Pre-made Rat Il18/IL-18/IL-1 gamma siRNA oligo Duplex | 29197 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo16173 | Pre-made Mouse Il18/Igif/Il-18 siRNA oligo Duplex | 16173 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo574151 | Pre-made Cynomolgus/Rhesus macaque IL18 siRNA oligo Duplex | 574151 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo493688 | Pre-made Cat/Feline IL18/IGIF siRNA oligo Duplex | 493688 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo403796 | Pre-made Dog/Canine IL18/IGIF siRNA oligo Duplex | 403796 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo281249 | Pre-made Bovines/Cattle IL18 siRNA oligo Duplex | 281249 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100034216 | Pre-made Equine/Horse IL18/IGIF/IL-18 siRNA oligo Duplex | 100034216 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-18/IL18 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T06671-Ab | Human | Anti-Human IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T06671-Ab | Rat | Anti-Rat IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T06671-Ab | Mouse | Anti-Mouse IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T06671-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T06671-Ab | Cat/Feline | Anti-Cat/Feline IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T06671-Ab | Dog/Canine | Anti-Dog/Canine IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T06671-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T06671-Ab | Equine/Horse | Anti-Equine/Horse IL-18/IL18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IL-18/IL18 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T06671-Ag | Human | Human IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T06671-Ag | Rat | Rat IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T06671-Ag | Mouse | Mouse IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T06671-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T06671-Ag | Cat/Feline | Cat/Feline IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T06671-Ag | Dog/Canine | Dog/Canine IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T06671-Ag | Bovines/Cattle | Bovines/Cattle IL-18/IL18 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T06671-Ag | Equine/Horse | Equine/Horse IL-18/IL18 recombinant protein | Mammalian cell | Detail |