Recombinant multi-species IL-18/IL18 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-18/IL18 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
The Alternative Names of target: IGIF,IL-1 gamma,IL-18,IL-1g,IL18,IL1F4,Iboctadekin,Igif,Il-18,Il18,Interferon gamma-inducing factor (IFN-gamma-inducing factor),Interleukin-1 gamma (IL-1 gamma),Interleukin-18

Target products collectionGo to IL-18/IL18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T06671-Ag-1/ GM-Tg-hg-T06671-Ag-2 Human IL-18/IL18 protein Human
GM-Tg-rg-T06671-Ag-1/ GM-Tg-rg-T06671-Ag-2 Rat IL-18/IL18 protein Rat
GM-Tg-mg-T06671-Ag-1/ GM-Tg-mg-T06671-Ag-2 Mouse IL-18/IL18 protein Mouse
GM-Tg-cynog-T06671-Ag-1/ GM-Tg-cynog-T06671-Ag-2 Cynomolgus/Rhesus macaque IL-18/IL18 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T06671-Ag-1/ GM-Tg-felg-T06671-Ag-2 Feline IL-18/IL18 protein Feline
GM-Tg-cang-T06671-Ag-1/ GM-Tg-cang-T06671-Ag-2 Canine IL-18/IL18 protein Canine
GM-Tg-bovg-T06671-Ag-1/ GM-Tg-bovg-T06671-Ag-2 Bovine IL-18/IL18 protein Bovine
GM-Tg-equg-T06671-Ag-1/ GM-Tg-equg-T06671-Ag-2 Equine IL-18/IL18 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T06671-Ag-1/ GM-Tg-hg-T06671-Ag-2; GM-Tg-rg-T06671-Ag-1/ GM-Tg-rg-T06671-Ag-2;
GM-Tg-mg-T06671-Ag-1/ GM-Tg-mg-T06671-Ag-2; GM-Tg-cynog-T06671-Ag-1/ GM-Tg-cynog-T06671-Ag-2;
GM-Tg-felg-T06671-Ag-1/ GM-Tg-felg-T06671-Ag-2; GM-Tg-cang-T06671-Ag-1/ GM-Tg-cang-T06671-Ag-2;
GM-Tg-bovg-T06671-Ag-1/ GM-Tg-bovg-T06671-Ag-2; GM-Tg-equg-T06671-Ag-1/ GM-Tg-equg-T06671-Ag-2
Products Name IL-18/IL18 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-18/IL18
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-18/IL18 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.