Explore SURVIVIN/BIRC5 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
| Target ID |
GM-T02677
|
| Target Name |
SURVIVIN/BIRC5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
332
|
| Gene ID |
100050808 (Equus caballus), 11799 (Mus musculus), 332 (Homo sapiens), 414925 (Bos taurus)
442936 (Canis lupus familiaris), 493835 (Felis catus), 64041 (Rattus norvegicus), 709565 (Macaca mulatta)
|
| Target Alternative Names |
AAC-11,AP14,API4,Api4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,BIRC5,Baculoviral IAP repeat-containing protein 5,Birc5,EPR-1,SURVIVIN,TIAP,survivin40
|
| Uniprot Accession |
O70201,O15392,Q6J1J1,Q8I009,Q6I6F4,Q9JHY7
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer, Breast Cancer, Malignant neoplasm of bladder
|
| Disease from KEGG |
Apoptosis, Apoptosis - multiple species, Hippo signaling pathway, Hepatitis B, Pathways in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer
|
| Gene Ensembl |
ENSMUSG00000017716, ENSG00000089685, ENSBTAG00000013573, ENSMMUG00000013767
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of SURVIVIN/BIRC5 cDNA Clones/ORF Plasmid
SURVIVIN/BIRC5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo332 | Pre-made Human BIRC5/API4/EPR-1 siRNA oligo Duplex | 332 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64041 | Pre-made Rat Birc5/AP14 siRNA oligo Duplex | 64041 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11799 | Pre-made Mouse Birc5/Api4/TIAP siRNA oligo Duplex | 11799 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709565 | Pre-made Cynomolgus/Rhesus macaque BIRC5 siRNA oligo Duplex | 709565 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493835 | Pre-made Cat/Feline BIRC5 siRNA oligo Duplex | 493835 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442936 | Pre-made Dog/Canine BIRC5 siRNA oligo Duplex | 442936 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo414925 | Pre-made Bovines/Cattle BIRC5 siRNA oligo Duplex | 414925 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050808 | Pre-made Equine/Horse BIRC5 siRNA oligo Duplex | 100050808 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SURVIVIN/BIRC5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T02677-Ab | Human | Anti-Human SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T02677-Ab | Rat | Anti-Rat SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T02677-Ab | Mouse | Anti-Mouse SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T02677-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T02677-Ab | Cat/Feline | Anti-Cat/Feline SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T02677-Ab | Dog/Canine | Anti-Dog/Canine SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T02677-Ab | Bovines/Cattle | Anti-Bovines/Cattle SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T02677-Ab | Equine/Horse | Anti-Equine/Horse SURVIVIN/BIRC5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
SURVIVIN/BIRC5 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T02677-Ag | Human | Human SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T02677-Ag | Rat | Rat SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T02677-Ag | Mouse | Mouse SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T02677-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T02677-Ag | Cat/Feline | Cat/Feline SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T02677-Ag | Dog/Canine | Dog/Canine SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T02677-Ag | Bovines/Cattle | Bovines/Cattle SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T02677-Ag | Equine/Horse | Equine/Horse SURVIVIN/BIRC5 recombinant protein | Mammalian cell | Detail |
