Explore XIAP gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
| Target ID |
GM-IP0058
|
| Target Name |
XIAP
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
331
|
| Gene ID |
100060870 (Equus caballus), 101090594 (Felis catus), 11798 (Mus musculus), 281647 (Bos taurus) 331 (Homo sapiens), 442989 (Canis lupus familiaris), 63879 (Rattus norvegicus), 698057 (Macaca mulatta)
|
| Target Alternative Names |
1110015C02Rik,API3,Aipa,Api3,BIRC4,Baculoviral IAP repeat-containing protein 4,Birc4,E3 ubiquitin-protein ligase XIAP,IAP-3,IAP-like protein (ILP,IAP3,ILP-1,ILP1,Inhibitor of apoptosis protein 3 (IAP-3,MIHA,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein (X-linked IAP),XIAP,XLP2,Xiap,hIAP-3,hIAP3,hIAP3),hILP),riap3
|
| Uniprot Accession |
Q60989,P98170,Q9R0I6
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
NF-kappa B signaling pathway, Apoptosis, Apoptosis - multiple species, Focal adhesion, NOD-like receptor signaling pathway, Toxoplasmosis, Human T-cell leukemia virus 1 infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Small cell lung cancer
|
| Gene Ensembl |
ENSECAG00000020071, ENSMUSG00000025860, ENSBTAG00000040350, ENSG00000101966, ENSCAFG00845025680, ENSMMUG00000032353
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of XIAP cDNA Clones/ORF Plasmid
XIAP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo331 | Pre-made Human XIAP/API3/ILP1 siRNA oligo Duplex | 331 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo63879 | Pre-made Rat Xiap/Api3/Birc4 siRNA oligo Duplex | 63879 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11798 | Pre-made Mouse Xiap/Aipa/Api3 siRNA oligo Duplex | 11798 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698057 | Pre-made Cynomolgus/Rhesus macaque XIAP/BIRC4 siRNA oligo Duplex | 698057 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090594 | Pre-made Cat/Feline XIAP siRNA oligo Duplex | 101090594 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442989 | Pre-made Dog/Canine XIAP/BIRC4 siRNA oligo Duplex | 442989 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281647 | Pre-made Bovines/Cattle XIAP/BIRC4 siRNA oligo Duplex | 281647 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060870 | Pre-made Equine/Horse XIAP siRNA oligo Duplex | 100060870 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
XIAP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0058-Ab | Human | Anti-Human XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0058-Ab | Rat | Anti-Rat XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0058-Ab | Mouse | Anti-Mouse XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0058-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0058-Ab | Cat/Feline | Anti-Cat/Feline XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0058-Ab | Dog/Canine | Anti-Dog/Canine XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0058-Ab | Bovines/Cattle | Anti-Bovines/Cattle XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0058-Ab | Equine/Horse | Anti-Equine/Horse XIAP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
XIAP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0058-Ag | Human | Human XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0058-Ag | Rat | Rat XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0058-Ag | Mouse | Mouse XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0058-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0058-Ag | Cat/Feline | Cat/Feline XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0058-Ag | Dog/Canine | Dog/Canine XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0058-Ag | Bovines/Cattle | Bovines/Cattle XIAP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0058-Ag | Equine/Horse | Equine/Horse XIAP recombinant protein | Mammalian cell | Detail |