Recombinant multi-species XIAP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine XIAP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
The Alternative Names of target: 1110015C02Rik,API3,Aipa,Api3,BIRC4,Baculoviral IAP repeat-containing protein 4,Birc4,E3 ubiquitin-protein ligase XIAP,IAP-3,IAP-like protein (ILP,IAP3,ILP-1,ILP1,Inhibitor of apoptosis protein 3 (IAP-3,MIHA,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein (X-linked IAP),XIAP,XLP2,Xiap,hIAP-3,hIAP3,hIAP3),hILP),riap3

Target products collectionGo to XIAP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0058-Ag-1/ GM-Tg-hg-IP0058-Ag-2 Human XIAP protein Human
GM-Tg-rg-IP0058-Ag-1/ GM-Tg-rg-IP0058-Ag-2 Rat XIAP protein Rat
GM-Tg-mg-IP0058-Ag-1/ GM-Tg-mg-IP0058-Ag-2 Mouse XIAP protein Mouse
GM-Tg-cynog-IP0058-Ag-1/ GM-Tg-cynog-IP0058-Ag-2 Cynomolgus/Rhesus macaque XIAP protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0058-Ag-1/ GM-Tg-felg-IP0058-Ag-2 Feline XIAP protein Feline
GM-Tg-cang-IP0058-Ag-1/ GM-Tg-cang-IP0058-Ag-2 Canine XIAP protein Canine
GM-Tg-bovg-IP0058-Ag-1/ GM-Tg-bovg-IP0058-Ag-2 Bovine XIAP protein Bovine
GM-Tg-equg-IP0058-Ag-1/ GM-Tg-equg-IP0058-Ag-2 Equine XIAP protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0058-Ag-1/ GM-Tg-hg-IP0058-Ag-2; GM-Tg-rg-IP0058-Ag-1/ GM-Tg-rg-IP0058-Ag-2;
GM-Tg-mg-IP0058-Ag-1/ GM-Tg-mg-IP0058-Ag-2; GM-Tg-cynog-IP0058-Ag-1/ GM-Tg-cynog-IP0058-Ag-2;
GM-Tg-felg-IP0058-Ag-1/ GM-Tg-felg-IP0058-Ag-2; GM-Tg-cang-IP0058-Ag-1/ GM-Tg-cang-IP0058-Ag-2;
GM-Tg-bovg-IP0058-Ag-1/ GM-Tg-bovg-IP0058-Ag-2; GM-Tg-equg-IP0058-Ag-1/ GM-Tg-equg-IP0058-Ag-2
Products Name XIAP protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name XIAP
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine XIAP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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