Explore AMPK Alpha 1/AMPK Alpha/PRKAA1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
| Target ID |
GM-TA017
|
| Target Name |
AMPK Alpha 1/AMPK Alpha/PRKAA1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5562
|
| Gene ID |
100009710 (Equus caballus), 101095885 (Felis catus), 105787 (Mus musculus), 479351 (Canis lupus familiaris) 540404 (Bos taurus), 5562 (Homo sapiens), 65248 (Rattus norvegicus), 695558 (Macaca mulatta)
|
| Target Alternative Names |
5'-AMP-activated protein kinase catalytic subunit alpha-1,AMPK,AMPK Alpha,AMPK Alpha 1,AMPK alpha 1,AMPK subunit alpha-1,AMPKa1,AMPKalpha1,Acetyl-CoA carboxylase kinase (ACACA kinase),C130083N04Rik,Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase),PRKAA1,Prkaa1,Tau-protein kinase PRKAA1
|
| Uniprot Accession |
Q5EG47,Q13131,P54645
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
FoxO signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Tight junction, Adipocytokine signaling pathway, Oxytocin signaling pathway, Insulin resistance, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000022617, ENSMUSG00000050697, ENSCAFG00845002768, ENSBTAG00000000013, ENSG00000132356, ENSMMUG00000023806
|
Pre-made viral vector of AMPK Alpha 1/AMPK Alpha/PRKAA1 cDNA Clones/ORF Plasmid
AMPK Alpha 1/AMPK Alpha/PRKAA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5562 | Pre-made Human PRKAA1/AMPK/AMPKa1 siRNA oligo Duplex | 5562 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo65248 | Pre-made Rat Prkaa1/AMPKalpha1 siRNA oligo Duplex | 65248 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo105787 | Pre-made Mouse Prkaa1/AMPKalpha1/C130083N04Rik siRNA oligo Duplex | 105787 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695558 | Pre-made Cynomolgus/Rhesus macaque PRKAA1 siRNA oligo Duplex | 695558 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095885 | Pre-made Cat/Feline PRKAA1 siRNA oligo Duplex | 101095885 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479351 | Pre-made Dog/Canine PRKAA1 siRNA oligo Duplex | 479351 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540404 | Pre-made Bovines/Cattle PRKAA1 siRNA oligo Duplex | 540404 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100009710 | Pre-made Equine/Horse PRKAA1 siRNA oligo Duplex | 100009710 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AMPK Alpha 1/AMPK Alpha/PRKAA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA017-Ab | Human | Anti-Human AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA017-Ab | Rat | Anti-Rat AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA017-Ab | Mouse | Anti-Mouse AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA017-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA017-Ab | Cat/Feline | Anti-Cat/Feline AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA017-Ab | Dog/Canine | Anti-Dog/Canine AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA017-Ab | Bovines/Cattle | Anti-Bovines/Cattle AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA017-Ab | Equine/Horse | Anti-Equine/Horse AMPK Alpha 1/AMPK Alpha/PRKAA1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA017-Ag | Human | Human AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA017-Ag | Rat | Rat AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA017-Ag | Mouse | Mouse AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA017-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA017-Ag | Cat/Feline | Cat/Feline AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA017-Ag | Dog/Canine | Dog/Canine AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA017-Ag | Bovines/Cattle | Bovines/Cattle AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA017-Ag | Equine/Horse | Equine/Horse AMPK Alpha 1/AMPK Alpha/PRKAA1 recombinant protein | Mammalian cell | Detail |