Explore CXCR4/CD184 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T96079
|
| Target Name |
CXCR4/CD184
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7852
|
| Gene ID |
100050974 (Equus caballus), 119863891 (Canis lupus familiaris), 12767 (Mus musculus), 281736 (Bos taurus)
493676 (Felis catus), 60628 (Rattus norvegicus), 707329 (Macaca mulatta), 7852 (Homo sapiens)
|
| Target Alternative Names |
C-X-C chemokine receptor type 4,CD184,CXC-R4,CXCR-4,CXCR4,Cmkar4,Cxcr4,D2S201E,FB22,Fusin,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,LPS-associated protein 3),Leukocyte-derived seven transmembrane domain receptor (LESTR),Lipopolysaccharide-associated protein 3 (LAP-3,NPY3R,NPYR,NPYRL,NPYY3R,PB-CKR,PBSF/SDF-1,Sdf1r,Stromal cell-derived factor 1 receptor (SDF-1 receptor),WHIM,WHIMS,WHIMS1,b2b220Clo
|
| Uniprot Accession |
P70658,P25930,P56498,O08565,P79394,P61073
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Calcium signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Axon guidance, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000003837, ENSCAFG00845010172,ENSCAFG00845025560, ENSMUSG00000045382, ENSMMUG00000011918, ENSG00000121966
|
| Target Classification |
GPCR, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CXCR4/CD184 cDNA Clones/ORF Plasmid
CXCR4/CD184 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7852 | Pre-made Human CXCR4/FB22/HM89 siRNA oligo Duplex | 7852 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo60628 | Pre-made Rat Cxcr4 siRNA oligo Duplex | 60628 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12767 | Pre-made Mouse Cxcr4/CD184/LESTR siRNA oligo Duplex | 12767 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707329 | Pre-made Cynomolgus/Rhesus macaque CXCR4 siRNA oligo Duplex | 707329 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493676 | Pre-made Cat/Feline CXCR4 siRNA oligo Duplex | 493676 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo119863891 | Pre-made Dog/Canine CXCR4 siRNA oligo Duplex | 119863891 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281736 | Pre-made Bovines/Cattle CXCR4 siRNA oligo Duplex | 281736 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050974 | Pre-made Equine/Horse CXCR4 siRNA oligo Duplex | 100050974 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CXCR4/CD184 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T96079-Ab | Human | Anti-Human CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T96079-Ab | Rat | Anti-Rat CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T96079-Ab | Mouse | Anti-Mouse CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T96079-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T96079-Ab | Cat/Feline | Anti-Cat/Feline CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T96079-Ab | Dog/Canine | Anti-Dog/Canine CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T96079-Ab | Bovines/Cattle | Anti-Bovines/Cattle CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T96079-Ab | Equine/Horse | Anti-Equine/Horse CXCR4/CD184 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CXCR4/CD184 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T96079-Ag | Human | Human CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T96079-Ag | Rat | Rat CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T96079-Ag | Mouse | Mouse CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T96079-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T96079-Ag | Cat/Feline | Cat/Feline CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T96079-Ag | Dog/Canine | Dog/Canine CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T96079-Ag | Bovines/Cattle | Bovines/Cattle CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T96079-Ag | Equine/Horse | Equine/Horse CXCR4/CD184 VLP (virus-like particle) | HEK293 | Products Developing |
