Explore SMAD7 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Target ID |
GM-T94695
|
Target Name |
SMAD7
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4092
|
Gene ID |
100033853 (Equus caballus), 101088277 (Felis catus), 17131 (Mus musculus), 4092 (Homo sapiens) 490570 (Canis lupus familiaris), 535916 (Bos taurus), 698338 (Macaca mulatta), 81516 (Rattus norvegicus)
|
Target Alternative Names |
CRCS3,MAD homolog 7,MADH7,MADH8,Madh7,Mothers against DPP homolog 7,Mothers against DPP homolog 8),Mothers against decapentaplegic homolog 7,Mothers against decapentaplegic homolog 8 (MAD homolog 8,SMAD family member 7 (SMAD 7,SMAD7,Smad7,hSMAD7)
|
Uniprot Accession |
O35253,O15105,O88406
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
Therapeutics Target, Cytokine Target
|
Disease |
cancer
|
Disease from KEGG |
TGF-beta signaling pathway, Hippo signaling pathway
|
Gene Ensembl |
ENSECAG00000020583, ENSMUSG00000025880, ENSG00000101665, ENSCAFG00845017036, ENSBTAG00000012441, ENSMMUG00000056276
|
Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of SMAD7 cDNA Clones/ORF Plasmid
SMAD7 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo4092 | Pre-made Human SMAD7/CRCS3/MADH7 siRNA oligo Duplex | 4092 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo81516 | Pre-made Rat Smad7/Madh7 siRNA oligo Duplex | 81516 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo17131 | Pre-made Mouse Smad7/Madh7 siRNA oligo Duplex | 17131 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo698338 | Pre-made Cynomolgus/Rhesus macaque SMAD7 siRNA oligo Duplex | 698338 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101088277 | Pre-made Cat/Feline SMAD7 siRNA oligo Duplex | 101088277 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo490570 | Pre-made Dog/Canine SMAD7 siRNA oligo Duplex | 490570 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo535916 | Pre-made Bovines/Cattle SMAD7 siRNA oligo Duplex | 535916 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100033853 | Pre-made Equine/Horse SMAD7 siRNA oligo Duplex | 100033853 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SMAD7 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T94695-Ab | Human | Anti-Human SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T94695-Ab | Rat | Anti-Rat SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T94695-Ab | Mouse | Anti-Mouse SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T94695-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T94695-Ab | Cat/Feline | Anti-Cat/Feline SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T94695-Ab | Dog/Canine | Anti-Dog/Canine SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T94695-Ab | Bovines/Cattle | Anti-Bovines/Cattle SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T94695-Ab | Equine/Horse | Anti-Equine/Horse SMAD7 monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
SMAD7 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T94695-Ag | Human | Human SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T94695-Ag | Rat | Rat SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T94695-Ag | Mouse | Mouse SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T94695-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T94695-Ag | Cat/Feline | Cat/Feline SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T94695-Ag | Dog/Canine | Dog/Canine SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T94695-Ag | Bovines/Cattle | Bovines/Cattle SMAD7 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T94695-Ag | Equine/Horse | Equine/Horse SMAD7 recombinant protein | Mammalian cell | Detail |