Recombinant multi-species SMAD7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
The Alternative Names of target: CRCS3,MAD homolog 7,MADH7,MADH8,Madh7,Mothers against DPP homolog 7,Mothers against DPP homolog 8),Mothers against decapentaplegic homolog 7,Mothers against decapentaplegic homolog 8 (MAD homolog 8,SMAD family member 7 (SMAD 7,SMAD7,Smad7,hSMAD7)

Target products collectionGo to SMAD7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T94695-Ag-1/ GM-Tg-hg-T94695-Ag-2 Human SMAD7 protein Human
GM-Tg-rg-T94695-Ag-1/ GM-Tg-rg-T94695-Ag-2 Rat SMAD7 protein Rat
GM-Tg-mg-T94695-Ag-1/ GM-Tg-mg-T94695-Ag-2 Mouse SMAD7 protein Mouse
GM-Tg-cynog-T94695-Ag-1/ GM-Tg-cynog-T94695-Ag-2 Cynomolgus/Rhesus macaque SMAD7 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T94695-Ag-1/ GM-Tg-felg-T94695-Ag-2 Feline SMAD7 protein Feline
GM-Tg-cang-T94695-Ag-1/ GM-Tg-cang-T94695-Ag-2 Canine SMAD7 protein Canine
GM-Tg-bovg-T94695-Ag-1/ GM-Tg-bovg-T94695-Ag-2 Bovine SMAD7 protein Bovine
GM-Tg-equg-T94695-Ag-1/ GM-Tg-equg-T94695-Ag-2 Equine SMAD7 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T94695-Ag-1/ GM-Tg-hg-T94695-Ag-2; GM-Tg-rg-T94695-Ag-1/ GM-Tg-rg-T94695-Ag-2;
GM-Tg-mg-T94695-Ag-1/ GM-Tg-mg-T94695-Ag-2; GM-Tg-cynog-T94695-Ag-1/ GM-Tg-cynog-T94695-Ag-2;
GM-Tg-felg-T94695-Ag-1/ GM-Tg-felg-T94695-Ag-2; GM-Tg-cang-T94695-Ag-1/ GM-Tg-cang-T94695-Ag-2;
GM-Tg-bovg-T94695-Ag-1/ GM-Tg-bovg-T94695-Ag-2; GM-Tg-equg-T94695-Ag-1/ GM-Tg-equg-T94695-Ag-2
Products Name SMAD7 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMAD7
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD7 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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