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Target
sublocation: Secreted Protein/Potential Cytokines.
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
| Target ID |
GM-T93237
|
| Target Name |
CCL21
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6366
|
| Gene ID |
101087275 (Felis catus), 18829 (Mus musculus), 298006 (Rattus norvegicus), 448796 (Canis lupus familiaris) 511112 (Bos taurus), 574183 (Macaca mulatta), 6366 (Homo sapiens)
|
| Target Alternative Names |
6CKBAC2,6Ckine,ALP,Beta-chemokine exodus-2,C-C motif chemokine 21,CCL21,CKb9,Ccl21,Ccl21a,Ccl21b,ECL,Gm1987,SCYA21,SCYA21a,SLC,Scya21,Scya21b,Secondary lymphoid-tissue chemokine (SLC),Small-inducible cytokine A21,TCA4,Tca4,plt
|
| Uniprot Accession |
P84444,Q8HYP5,O00585
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer, ovarian cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NF-kappa B signaling pathway
|
| Gene Ensembl |
ENSMUSG00000094686, ENSCAFG00845005361, ENSBTAG00000010161, ENSMMUG00000063081, ENSG00000137077
|
Pre-made viral vector of CCL21 cDNA Clones/ORF Plasmid
CCL21 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6366 | Pre-made Human CCL21/ECL/SLC siRNA oligo Duplex | 6366 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo298006 | Pre-made Rat Ccl21/Ccl21b siRNA oligo Duplex | 298006 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18829 | Pre-made Mouse Ccl21a/ALP/SLC siRNA oligo Duplex | 18829 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574183 | Pre-made Cynomolgus/Rhesus macaque CCL21 siRNA oligo Duplex | 574183 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087275 | Pre-made Cat/Feline CCL21 siRNA oligo Duplex | 101087275 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo448796 | Pre-made Dog/Canine CCL21 siRNA oligo Duplex | 448796 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511112 | Pre-made Bovines/Cattle CCL21 siRNA oligo Duplex | 511112 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
CCL21 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T93237-Ab | Human | Anti-Human CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T93237-Ab | Rat | Anti-Rat CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T93237-Ab | Mouse | Anti-Mouse CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T93237-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T93237-Ab | Cat/Feline | Anti-Cat/Feline CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T93237-Ab | Dog/Canine | Anti-Dog/Canine CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T93237-Ab | Bovines/Cattle | Anti-Bovines/Cattle CCL21 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CCL21 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T93237-Ag | Human | Human CCL21 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T93237-Ag | Rat | Rat CCL21 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T93237-Ag | Mouse | Mouse CCL21 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T93237-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CCL21 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T93237-Ag | Cat/Feline | Cat/Feline CCL21 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T93237-Ag | Dog/Canine | Dog/Canine CCL21 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T93237-Ag | Bovines/Cattle | Bovines/Cattle CCL21 recombinant protein | Mammalian cell | Detail |