Explore Amphiregulin/AREG gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
| Target ID |
GM-T92834
|
| Target Name |
Amphiregulin/AREG
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
374
|
| Gene ID |
100050528 (Equus caballus), 101081041 (Felis catus), 11839 (Mus musculus), 29183 (Rattus norvegicus) 374 (Homo sapiens), 475176 (Canis lupus familiaris), 538751 (Bos taurus), 702396 (Macaca mulatta)
|
| Target Alternative Names |
AR,AREG,AREGB,Amphiregulin,Areg,CRDGF,Colorectum cell-derived growth factor (CRDGF),Mcub,SDGF,Sdgf
|
| Uniprot Accession |
P31955,P24338,P15514
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, ErbB signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, Colorectal cancer
|
| Gene Ensembl |
ENSECAG00000022525, ENSMUSG00000029378, ENSG00000109321, ENSCAFG00845006713, ENSBTAG00000018134, ENSMMUG00000002314
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of Amphiregulin/AREG cDNA Clones/ORF Plasmid
Amphiregulin/AREG siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo374 | Pre-made Human AREG/AR/SDGF siRNA oligo Duplex | 374 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29183 | Pre-made Rat Areg siRNA oligo Duplex | 29183 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11839 | Pre-made Mouse Areg/AR/Mcub siRNA oligo Duplex | 11839 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702396 | Pre-made Cynomolgus/Rhesus macaque AREG/AREGB siRNA oligo Duplex | 702396 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081041 | Pre-made Cat/Feline AREG siRNA oligo Duplex | 101081041 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475176 | Pre-made Dog/Canine AREG/AREGB siRNA oligo Duplex | 475176 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538751 | Pre-made Bovines/Cattle AREG/AREGB siRNA oligo Duplex | 538751 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050528 | Pre-made Equine/Horse AREG siRNA oligo Duplex | 100050528 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Amphiregulin/AREG antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T92834-Ab | Human | Anti-Human Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T92834-Ab | Rat | Anti-Rat Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T92834-Ab | Mouse | Anti-Mouse Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T92834-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T92834-Ab | Cat/Feline | Anti-Cat/Feline Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T92834-Ab | Dog/Canine | Anti-Dog/Canine Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T92834-Ab | Bovines/Cattle | Anti-Bovines/Cattle Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T92834-Ab | Equine/Horse | Anti-Equine/Horse Amphiregulin/AREG monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
Amphiregulin/AREG recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T92834-Ag | Human | Human Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T92834-Ag | Rat | Rat Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T92834-Ag | Mouse | Mouse Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T92834-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T92834-Ag | Cat/Feline | Cat/Feline Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T92834-Ag | Dog/Canine | Dog/Canine Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T92834-Ag | Bovines/Cattle | Bovines/Cattle Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T92834-Ag | Equine/Horse | Equine/Horse Amphiregulin/AREG recombinant protein | Mammalian cell | Detail |