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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T89859
|
| Target Name |
NR0B2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8431
|
| Gene ID |
101081062 (Felis catus), 117274 (Rattus norvegicus), 138915016 (Equus caballus), 23957 (Mus musculus) 514770 (Bos taurus), 612125 (Canis lupus familiaris), 715170 (Macaca mulatta), 8431 (Homo sapiens)
|
| Target Alternative Names |
NR0B2,Nr0b2,Nuclear receptor subfamily 0 group B member 2,Orphan nuclear receptor SHP,SHP,SHP-1,SHP1,Shp,Shp1,Small heterodimer partner
|
| Uniprot Accession |
P97947,Q62227,Q15466
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Bile secretion
|
| Gene Ensembl |
ENSMUSG00000037583, ENSBTAG00000014848, ENSCAFG00845011182, ENSMMUG00000010291, ENSG00000131910
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of NR0B2 cDNA Clones/ORF Plasmid
NR0B2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8431 | Pre-made Human NR0B2/SHP/SHP1 siRNA oligo Duplex | 8431 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117274 | Pre-made Rat Nr0b2/Shp siRNA oligo Duplex | 117274 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo23957 | Pre-made Mouse Nr0b2/SHP/Shp1 siRNA oligo Duplex | 23957 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715170 | Pre-made Cynomolgus/Rhesus macaque NR0B2 siRNA oligo Duplex | 715170 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081062 | Pre-made Cat/Feline NR0B2 siRNA oligo Duplex | 101081062 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612125 | Pre-made Dog/Canine NR0B2 siRNA oligo Duplex | 612125 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514770 | Pre-made Bovines/Cattle NR0B2 siRNA oligo Duplex | 514770 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo138915016 | Pre-made Equine/Horse NR0B2 siRNA oligo Duplex | 138915016 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NR0B2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T89859-Ab | Human | Anti-Human NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T89859-Ab | Rat | Anti-Rat NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T89859-Ab | Mouse | Anti-Mouse NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T89859-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T89859-Ab | Cat/Feline | Anti-Cat/Feline NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T89859-Ab | Dog/Canine | Anti-Dog/Canine NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T89859-Ab | Bovines/Cattle | Anti-Bovines/Cattle NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T89859-Ab | Equine/Horse | Anti-Equine/Horse NR0B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NR0B2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T89859-Ag | Human | Human NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T89859-Ag | Rat | Rat NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T89859-Ag | Mouse | Mouse NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T89859-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T89859-Ag | Cat/Feline | Cat/Feline NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T89859-Ag | Dog/Canine | Dog/Canine NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T89859-Ag | Bovines/Cattle | Bovines/Cattle NR0B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T89859-Ag | Equine/Horse | Equine/Horse NR0B2 recombinant protein | Mammalian cell | Detail |