Recombinant multi-species NR0B2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR0B2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
The Alternative Names of target: NR0B2,Nr0b2,Nuclear receptor subfamily 0 group B member 2,Orphan nuclear receptor SHP,SHP,SHP-1,SHP1,Shp,Shp1,Small heterodimer partner

Target products collectionGo to NR0B2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T89859-Ag-1/ GM-Tg-hg-T89859-Ag-2 Human NR0B2 protein Human
GM-Tg-rg-T89859-Ag-1/ GM-Tg-rg-T89859-Ag-2 Rat NR0B2 protein Rat
GM-Tg-mg-T89859-Ag-1/ GM-Tg-mg-T89859-Ag-2 Mouse NR0B2 protein Mouse
GM-Tg-cynog-T89859-Ag-1/ GM-Tg-cynog-T89859-Ag-2 Cynomolgus/Rhesus macaque NR0B2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T89859-Ag-1/ GM-Tg-felg-T89859-Ag-2 Feline NR0B2 protein Feline
GM-Tg-cang-T89859-Ag-1/ GM-Tg-cang-T89859-Ag-2 Canine NR0B2 protein Canine
GM-Tg-bovg-T89859-Ag-1/ GM-Tg-bovg-T89859-Ag-2 Bovine NR0B2 protein Bovine
GM-Tg-equg-T89859-Ag-1/ GM-Tg-equg-T89859-Ag-2 Equine NR0B2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T89859-Ag-1/ GM-Tg-hg-T89859-Ag-2; GM-Tg-rg-T89859-Ag-1/ GM-Tg-rg-T89859-Ag-2;
GM-Tg-mg-T89859-Ag-1/ GM-Tg-mg-T89859-Ag-2; GM-Tg-cynog-T89859-Ag-1/ GM-Tg-cynog-T89859-Ag-2;
GM-Tg-felg-T89859-Ag-1/ GM-Tg-felg-T89859-Ag-2; GM-Tg-cang-T89859-Ag-1/ GM-Tg-cang-T89859-Ag-2;
GM-Tg-bovg-T89859-Ag-1/ GM-Tg-bovg-T89859-Ag-2; GM-Tg-equg-T89859-Ag-1/ GM-Tg-equg-T89859-Ag-2
Products Name NR0B2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NR0B2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR0B2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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