Explore CDK6 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T89361
|
| Target Name |
CDK6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1021
|
| Gene ID |
100037415 (Felis catus), 100061625 (Equus caballus), 1021 (Homo sapiens), 114483 (Rattus norvegicus) 12571 (Mus musculus), 511754 (Bos taurus), 609920 (Canis lupus familiaris), 701822 (Macaca mulatta)
|
| Target Alternative Names |
CDK6,Cdk6,Cell division protein kinase 6,Crk2,Cyclin-dependent kinase 6,MCPH12,PLSTIRE,Serine/threonine-protein kinase PLSTIRE
|
| Uniprot Accession |
Q00534,Q64261
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, breast tumor
|
| Disease from KEGG |
p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Cushing syndrome, Hepatitis C, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Pancreatic cancer, Glioma, Melanoma, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma
|
| Gene Ensembl |
ENSECAG00000016512, ENSG00000105810, ENSMUSG00000040274, ENSBTAG00000044023, ENSCAFG00845013226, ENSMMUG00000008698
|
| Target Classification |
Kinase
|
Pre-made viral vector of CDK6 cDNA Clones/ORF Plasmid
CDK6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1021 | Pre-made Human CDK6/MCPH12/PLSTIRE siRNA oligo Duplex | 1021 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114483 | Pre-made Rat Cdk6 siRNA oligo Duplex | 114483 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12571 | Pre-made Mouse Cdk6/Crk2 siRNA oligo Duplex | 12571 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701822 | Pre-made Cynomolgus/Rhesus macaque CDK6 siRNA oligo Duplex | 701822 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100037415 | Pre-made Cat/Feline CDK6 siRNA oligo Duplex | 100037415 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609920 | Pre-made Dog/Canine CDK6 siRNA oligo Duplex | 609920 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511754 | Pre-made Bovines/Cattle CDK6 siRNA oligo Duplex | 511754 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061625 | Pre-made Equine/Horse CDK6 siRNA oligo Duplex | 100061625 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CDK6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T89361-Ab | Human | Anti-Human CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T89361-Ab | Rat | Anti-Rat CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T89361-Ab | Mouse | Anti-Mouse CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T89361-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T89361-Ab | Cat/Feline | Anti-Cat/Feline CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T89361-Ab | Dog/Canine | Anti-Dog/Canine CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T89361-Ab | Bovines/Cattle | Anti-Bovines/Cattle CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T89361-Ab | Equine/Horse | Anti-Equine/Horse CDK6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CDK6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T89361-Ag | Human | Human CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T89361-Ag | Rat | Rat CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T89361-Ag | Mouse | Mouse CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T89361-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T89361-Ag | Cat/Feline | Cat/Feline CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T89361-Ag | Dog/Canine | Dog/Canine CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T89361-Ag | Bovines/Cattle | Bovines/Cattle CDK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T89361-Ag | Equine/Horse | Equine/Horse CDK6 recombinant protein | Mammalian cell | Detail |