Recombinant multi-species CDK6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
The Alternative Names of target: CDK6,Cdk6,Cell division protein kinase 6,Crk2,Cyclin-dependent kinase 6,MCPH12,PLSTIRE,Serine/threonine-protein kinase PLSTIRE

Target products collectionGo to CDK6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T89361-Ag-1/ GM-Tg-hg-T89361-Ag-2 Human CDK6 protein Human
GM-Tg-rg-T89361-Ag-1/ GM-Tg-rg-T89361-Ag-2 Rat CDK6 protein Rat
GM-Tg-mg-T89361-Ag-1/ GM-Tg-mg-T89361-Ag-2 Mouse CDK6 protein Mouse
GM-Tg-cynog-T89361-Ag-1/ GM-Tg-cynog-T89361-Ag-2 Cynomolgus/Rhesus macaque CDK6 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T89361-Ag-1/ GM-Tg-felg-T89361-Ag-2 Feline CDK6 protein Feline
GM-Tg-cang-T89361-Ag-1/ GM-Tg-cang-T89361-Ag-2 Canine CDK6 protein Canine
GM-Tg-bovg-T89361-Ag-1/ GM-Tg-bovg-T89361-Ag-2 Bovine CDK6 protein Bovine
GM-Tg-equg-T89361-Ag-1/ GM-Tg-equg-T89361-Ag-2 Equine CDK6 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T89361-Ag-1/ GM-Tg-hg-T89361-Ag-2; GM-Tg-rg-T89361-Ag-1/ GM-Tg-rg-T89361-Ag-2;
GM-Tg-mg-T89361-Ag-1/ GM-Tg-mg-T89361-Ag-2; GM-Tg-cynog-T89361-Ag-1/ GM-Tg-cynog-T89361-Ag-2;
GM-Tg-felg-T89361-Ag-1/ GM-Tg-felg-T89361-Ag-2; GM-Tg-cang-T89361-Ag-1/ GM-Tg-cang-T89361-Ag-2;
GM-Tg-bovg-T89361-Ag-1/ GM-Tg-bovg-T89361-Ag-2; GM-Tg-equg-T89361-Ag-1/ GM-Tg-equg-T89361-Ag-2
Products Name CDK6 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CDK6
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.