Explore TNF Beta/TNF beta/LTA gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
| Target ID |
GM-T85158
|
| Target Name |
TNF Beta/TNF beta/LTA
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4049
|
| Gene ID |
100058321 (Equus caballus), 101084961 (Felis catus), 16992 (Mus musculus), 25008 (Rattus norvegicus) 280845 (Bos taurus), 4049 (Homo sapiens), 607183 (Canis lupus familiaris), 715425 (Macaca mulatta)
|
| Target Alternative Names |
LT,LT-[a],LT-alpha,LTA,LT[a],LTalpha,Lta,Ltx,Lymphotoxin-alpha,TNF Beta,TNF beta,TNF-beta,TNFB,TNFSF1,TNLG1E,Tnfb,Tnfsf1b,Tnlg1e,Tumor necrosis factor ligand superfamily member 1,hlb382
|
| Uniprot Accession |
P09225,Q06332,Q06600,P01374,Q5WR07,Q5TM20
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Human T-cell leukemia virus 1 infection
|
| Gene Ensembl |
ENSMUSG00000024402, ENSBTAG00000000016, ENSG00000226979, ENSCAFG00845010521, ENSMMUG00000008843
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of TNF Beta/TNF beta/LTA cDNA Clones/ORF Plasmid
TNF Beta/TNF beta/LTA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4049 | Pre-made Human LTA/LT/TNFB siRNA oligo Duplex | 4049 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25008 | Pre-made Rat Lta/Tnfb siRNA oligo Duplex | 25008 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16992 | Pre-made Mouse Lta/LT/Ltx siRNA oligo Duplex | 16992 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715425 | Pre-made Cynomolgus/Rhesus macaque LTA siRNA oligo Duplex | 715425 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084961 | Pre-made Cat/Feline LTA/TNLG1E siRNA oligo Duplex | 101084961 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607183 | Pre-made Dog/Canine LTA/TNFB/TNFSF1 siRNA oligo Duplex | 607183 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280845 | Pre-made Bovines/Cattle LTA siRNA oligo Duplex | 280845 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058321 | Pre-made Equine/Horse LTA/TNLG1E siRNA oligo Duplex | 100058321 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TNF Beta/TNF beta/LTA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T85158-Ab | Human | Anti-Human TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T85158-Ab | Rat | Anti-Rat TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T85158-Ab | Mouse | Anti-Mouse TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T85158-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T85158-Ab | Cat/Feline | Anti-Cat/Feline TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T85158-Ab | Dog/Canine | Anti-Dog/Canine TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T85158-Ab | Bovines/Cattle | Anti-Bovines/Cattle TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T85158-Ab | Equine/Horse | Anti-Equine/Horse TNF Beta/TNF beta/LTA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TNF Beta/TNF beta/LTA VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T85158-Ag | Human | Human TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T85158-Ag | Rat | Rat TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T85158-Ag | Mouse | Mouse TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T85158-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T85158-Ag | Cat/Feline | Cat/Feline TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T85158-Ag | Dog/Canine | Dog/Canine TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T85158-Ag | Bovines/Cattle | Bovines/Cattle TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T85158-Ag | Equine/Horse | Equine/Horse TNF Beta/TNF beta/LTA VLP (virus-like particle) | HEK293 | Products Developing |