Explore LEP/Leptin gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T79485
|
| Target Name |
LEP/Leptin
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3952
|
| Gene ID |
100034042 (Equus caballus), 16846 (Mus musculus), 25608 (Rattus norvegicus), 280836 (Bos taurus) 3952 (Homo sapiens), 403616 (Canis lupus familiaris), 493838 (Felis catus), 698728 (Macaca mulatta)
|
| Target Alternative Names |
LEP,LEPD,Lep,Leptin,OB,OBS,Obese protein,Obesity factor,ob,obese
|
| Uniprot Accession |
Q9TU09,P41160,P50596,P50595,P41159,O02720,Q9N2C1,Q28504
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, JAK-STAT signaling pathway, Adipocytokine signaling pathway
|
| Gene Ensembl |
ENSMUSG00000059201, ENSG00000174697, ENSCAFG00845025165, ENSMMUG00000005322
|
Pre-made viral vector of LEP/Leptin cDNA Clones/ORF Plasmid
LEP/Leptin siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3952 | Pre-made Human LEP/OB/OBS siRNA oligo Duplex | 3952 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25608 | Pre-made Rat Lep/OB/obese siRNA oligo Duplex | 25608 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16846 | Pre-made Mouse Lep/ob/obese siRNA oligo Duplex | 16846 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698728 | Pre-made Cynomolgus/Rhesus macaque LEP/OB siRNA oligo Duplex | 698728 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493838 | Pre-made Cat/Feline LEP/ob siRNA oligo Duplex | 493838 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403616 | Pre-made Dog/Canine LEP/OB siRNA oligo Duplex | 403616 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280836 | Pre-made Bovines/Cattle LEP/ob siRNA oligo Duplex | 280836 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034042 | Pre-made Equine/Horse LEP siRNA oligo Duplex | 100034042 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LEP/Leptin antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T79485-Ab | Human | Anti-Human LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T79485-Ab | Rat | Anti-Rat LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T79485-Ab | Mouse | Anti-Mouse LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T79485-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T79485-Ab | Cat/Feline | Anti-Cat/Feline LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T79485-Ab | Dog/Canine | Anti-Dog/Canine LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T79485-Ab | Bovines/Cattle | Anti-Bovines/Cattle LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T79485-Ab | Equine/Horse | Anti-Equine/Horse LEP/Leptin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
LEP/Leptin recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T79485-Ag | Human | Human LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T79485-Ag | Rat | Rat LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T79485-Ag | Mouse | Mouse LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T79485-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T79485-Ag | Cat/Feline | Cat/Feline LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T79485-Ag | Dog/Canine | Dog/Canine LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T79485-Ag | Bovines/Cattle | Bovines/Cattle LEP/Leptin recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T79485-Ag | Equine/Horse | Equine/Horse LEP/Leptin recombinant protein | Mammalian cell | Detail |