LEP/Leptin Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore LEP/Leptin gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017]

Target ID GM-T79485
Target Name LEP/Leptin
Gene Group ldentifer
(Target Gene ID in Homo species)
3952
Gene ID 100034042 (Equus caballus), 16846 (Mus musculus), 25608 (Rattus norvegicus), 280836 (Bos taurus)
3952 (Homo sapiens), 403616 (Canis lupus familiaris), 493838 (Felis catus), 698728 (Macaca mulatta)
Target Alternative Names LEP,LEPD,Lep,Leptin,OB,OBS,Obese protein,Obesity factor,ob,obese
Uniprot Accession Q9TU09,P41160,P50596,P50595,P41159,O02720,Q9N2C1,Q28504
Protein Sub-location Secreted Protein/Potential Cytokines
Category Therapeutics Target, Cytokine Target
Disease from KEGG Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, JAK-STAT signaling pathway, Adipocytokine signaling pathway
Gene Ensembl ENSMUSG00000059201, ENSG00000174697, ENSCAFG00845025165, ENSMMUG00000005322


Pre-made viral vector of LEP/Leptin cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP001963Human LEP/LEPD/OB Lentivirus plasmidNM_000230.23952HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV001867Human LEP/LEPD/OB Lentivirus plasmidNM_000230.33952HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP001963Human LEP/LEPD/OB Lentivirus particleNM_000230.23952HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV001867Human LEP/LEPD/OB Lentivirus particleNM_000230.33952HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
pGMAD001143Rat Lep/OB/obese Adenovirus plasmidNM_013076.325608RatAdenovirus plasmidEGFP3xflag (C-Terminal)EF1Detail
vGMAD001143Rat Lep/OB/obese Adenovirus particleNM_013076.325608RatAdenovirus particleEGFP3xflag (C-Terminal)EF1Detail
pGMAD000615Mouse Lep/ob/obese Adenovirus plasmidNM_008493.316846MouseAdenovirus plasmidGFPNullEF1Detail
pGMAAV001065Mouse Lep/ob/obese Adeno-associate virus(AAV) plasmidNM_008493.316846MouseAdeno-associate virus(AAV) plasmidmCherryNullFABP4Detail
pGMAAV001503Mouse Lep/ob/obese Adeno-associate virus(AAV) plasmidNM_008493.316846MouseAdeno-associate virus(AAV) plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLPm000126Mouse Lep/ob/obese Lentivirus plasmidNM_00849316846MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMAD000615Mouse Lep/ob/obese Adenovirus particleNM_008493.316846MouseAdenovirus particleGFPNullEF1Detail
vGMAAV001065Mouse Lep/ob/obese Adeno-associate virus(AAV) particleNM_008493.316846MouseAdeno-associate virus(AAV) particlemCherryNullFABP4Detail
vGMAAV001503Mouse Lep/ob/obese Adeno-associate virus(AAV) particleNM_008493.316846MouseAdeno-associate virus(AAV) particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLPm000126Mouse Lep/ob/obese Lentivirus particleNM_00849316846MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


LEP/Leptin siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo3952Pre-made Human LEP/OB/OBS siRNA oligo Duplex3952HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo25608Pre-made Rat Lep/OB/obese siRNA oligo Duplex25608RatIn-vitro grade; in-vivo gradeDetail
pGMoligo16846Pre-made Mouse Lep/ob/obese siRNA oligo Duplex16846MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo698728Pre-made Cynomolgus/Rhesus macaque LEP/OB siRNA oligo Duplex698728Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo493838Pre-made Cat/Feline LEP/ob siRNA oligo Duplex493838Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo403616Pre-made Dog/Canine LEP/OB siRNA oligo Duplex403616Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo280836Pre-made Bovines/Cattle LEP/ob siRNA oligo Duplex280836Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100034042Pre-made Equine/Horse LEP siRNA oligo Duplex100034042Equine/HorseIn-vitro grade; in-vivo gradeDetail


LEP/Leptin antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T79485-AbHumanAnti-Human LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-rg-T79485-AbRatAnti-Rat LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-mg-T79485-AbMouseAnti-Mouse LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cynog-T79485-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-felg-T79485-AbCat/FelineAnti-Cat/Feline LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cang-T79485-AbDog/CanineAnti-Dog/Canine LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-bovg-T79485-AbBovines/CattleAnti-Bovines/Cattle LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-equg-T79485-AbEquine/HorseAnti-Equine/Horse LEP/Leptin monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail


LEP/Leptin recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T79485-AgHumanHuman LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-rg-T79485-AgRatRat LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-mg-T79485-AgMouseMouse LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-cynog-T79485-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-felg-T79485-AgCat/FelineCat/Feline LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-cang-T79485-AgDog/CanineDog/Canine LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-bovg-T79485-AgBovines/CattleBovines/Cattle LEP/Leptin recombinant proteinMammalian cellDetail
GM-Tg-equg-T79485-AgEquine/HorseEquine/Horse LEP/Leptin recombinant proteinMammalian cellDetail