Recombinant multi-species LEP/Leptin protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LEP/Leptin protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017]
The Alternative Names of target: LEP,LEPD,Lep,Leptin,OB,OBS,Obese protein,Obesity factor,ob,obese

Target products collectionGo to LEP/Leptin products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T79485-Ag-1/ GM-Tg-hg-T79485-Ag-2 Human LEP/Leptin protein Human
GM-Tg-rg-T79485-Ag-1/ GM-Tg-rg-T79485-Ag-2 Rat LEP/Leptin protein Rat
GM-Tg-mg-T79485-Ag-1/ GM-Tg-mg-T79485-Ag-2 Mouse LEP/Leptin protein Mouse
GM-Tg-cynog-T79485-Ag-1/ GM-Tg-cynog-T79485-Ag-2 Cynomolgus/Rhesus macaque LEP/Leptin protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T79485-Ag-1/ GM-Tg-felg-T79485-Ag-2 Feline LEP/Leptin protein Feline
GM-Tg-cang-T79485-Ag-1/ GM-Tg-cang-T79485-Ag-2 Canine LEP/Leptin protein Canine
GM-Tg-bovg-T79485-Ag-1/ GM-Tg-bovg-T79485-Ag-2 Bovine LEP/Leptin protein Bovine
GM-Tg-equg-T79485-Ag-1/ GM-Tg-equg-T79485-Ag-2 Equine LEP/Leptin protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T79485-Ag-1/ GM-Tg-hg-T79485-Ag-2; GM-Tg-rg-T79485-Ag-1/ GM-Tg-rg-T79485-Ag-2;
GM-Tg-mg-T79485-Ag-1/ GM-Tg-mg-T79485-Ag-2; GM-Tg-cynog-T79485-Ag-1/ GM-Tg-cynog-T79485-Ag-2;
GM-Tg-felg-T79485-Ag-1/ GM-Tg-felg-T79485-Ag-2; GM-Tg-cang-T79485-Ag-1/ GM-Tg-cang-T79485-Ag-2;
GM-Tg-bovg-T79485-Ag-1/ GM-Tg-bovg-T79485-Ag-2; GM-Tg-equg-T79485-Ag-1/ GM-Tg-equg-T79485-Ag-2
Products Name LEP/Leptin protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LEP/Leptin
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LEP/Leptin protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.