JNK/MAPK9/JNK2 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
| Target ID | GM-T69375 |
| Target Name | JNK/MAPK9/JNK2 |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
5601 |
| Gene ID |
100057961 (Equus caballus), 101084765 (Felis catus), 26420 (Mus musculus), 474652 (Canis lupus familiaris) 50658 (Rattus norvegicus), 534125 (Bos taurus), 5601 (Homo sapiens), 715782 (Macaca mulatta) |
| Target Alternative Names | MAPK9,Mapk9,JNK2,Prkm9,p54aSAPK,SAPK,p54a,JNK2A,JNK2B,PRKM9,JNK-55,SAPK1a,JNK2BETA,JNK2ALPHA |
| Uniprot Accession | Q9WTU6,P49186,P45984 |
| Uniprot Entry Name | |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | |
| Disease from KEGG | Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, cAMP signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, Apoptosis, Apoptosis - multiple species, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Alcoholic liver disease, Alzheimer disease, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Pertussis, Yersinia infection, Chagas disease, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Choline metabolism in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis |
| Gene Ensembl | ENSECAG00000021489, ENSMUSG00000020366, ENSCAFG00845006710, ENSBTAG00000004709, ENSG00000050748, ENSMMUG00000001728 |
| Target Classification | Kinase |
Pre-made viral vector of JNK/MAPK9/JNK2 cDNA Clones/ORF Plasmid
| Cat No. | Product Name | NMID | GeneID | Species | Type | Marker | Fusion Tag | Promoter | Detail |
|---|---|---|---|---|---|---|---|---|---|
| pGMLP000516 | Human MAPK9/JNK-55/JNK2 Lentivirus plasmid | NM_002752 | 5601 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLP005803 | Human MAPK9/JNK-55/JNK2 Lentivirus plasmid | NM_002752.4 | 5601 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMAP000176 | Human MAPK9/JNK-55/JNK2 Adenovirus plasmid | BC032539 | 5601 | Human | Adenovirus plasmid | GFP | 3xflag (C-Terminal) | EF1 | Detail |
| vGMLP000516 | Human MAPK9/JNK-55/JNK2 Lentivirus particle | NM_002752 | 5601 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLP005803 | Human MAPK9/JNK-55/JNK2 Lentivirus particle | NM_002752.4 | 5601 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMAP000176 | Human MAPK9/JNK-55/JNK2 Adenovirus particle | BC032539 | 5601 | Human | Adenovirus particle | GFP | 3xflag (C-Terminal) | EF1 | Detail |
JNK/MAPK9/JNK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|---|---|---|---|---|
| pGMoligo5601 | Pre-made Human MAPK9/JNK2/SAPK siRNA oligo Duplex | 5601 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50658 | Pre-made Rat Mapk9/SAPK siRNA oligo Duplex | 50658 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26420 | Pre-made Mouse Mapk9/JNK2/Prkm9 siRNA oligo Duplex | 26420 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715782 | Pre-made Cynomolgus/Rhesus macaque MAPK9 siRNA oligo Duplex | 715782 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084765 | Pre-made Cat/Feline MAPK9 siRNA oligo Duplex | 101084765 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474652 | Pre-made Dog/Canine MAPK9 siRNA oligo Duplex | 474652 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534125 | Pre-made Bovines/Cattle MAPK9/JNK2 siRNA oligo Duplex | 534125 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057961 | Pre-made Equine/Horse MAPK9 siRNA oligo Duplex | 100057961 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
JNK/MAPK9/JNK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|---|---|---|---|---|
| GM-Tg-hg-T69375-Ab | Human | Anti-Human JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T69375-Ab | Rat | Anti-Rat JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T69375-Ab | Mouse | Anti-Mouse JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T69375-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T69375-Ab | Cat/Feline | Anti-Cat/Feline JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T69375-Ab | Dog/Canine | Anti-Dog/Canine JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T69375-Ab | Bovines/Cattle | Anti-Bovines/Cattle JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T69375-Ab | Equine/Horse | Anti-Equine/Horse JNK/MAPK9/JNK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
JNK/MAPK9/JNK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|---|---|---|---|
| GM-Tg-hg-T69375-Ag | Human | Human JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T69375-Ag | Rat | Rat JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T69375-Ag | Mouse | Mouse JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T69375-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T69375-Ag | Cat/Feline | Cat/Feline JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T69375-Ag | Dog/Canine | Dog/Canine JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T69375-Ag | Bovines/Cattle | Bovines/Cattle JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T69375-Ag | Equine/Horse | Equine/Horse JNK/MAPK9/JNK2 recombinant protein | Mammalian cell | Detail |