Recombinant multi-species JNK/MAPK9/JNK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JNK/MAPK9/JNK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
The Alternative Names of target: JNK,JNK-55,JNK2,JNK2A,JNK2ALPHA,JNK2B,JNK2BETA,MAP kinase 9,MAPK 9,MAPK9,Mapk9,Mitogen-activated protein kinase 9,PRKM9,Prkm9,SAPK,SAPK1a,Stress-activated protein kinase 1a (SAPK1a),Stress-activated protein kinase JNK2,c-Jun N-terminal kinase 2,p54a,p54aSAPK

Target products collectionGo to JNK/MAPK9/JNK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T69375-Ag-1/ GM-Tg-hg-T69375-Ag-2 Human JNK/MAPK9/JNK2 protein Human
GM-Tg-rg-T69375-Ag-1/ GM-Tg-rg-T69375-Ag-2 Rat JNK/MAPK9/JNK2 protein Rat
GM-Tg-mg-T69375-Ag-1/ GM-Tg-mg-T69375-Ag-2 Mouse JNK/MAPK9/JNK2 protein Mouse
GM-Tg-cynog-T69375-Ag-1/ GM-Tg-cynog-T69375-Ag-2 Cynomolgus/Rhesus macaque JNK/MAPK9/JNK2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T69375-Ag-1/ GM-Tg-felg-T69375-Ag-2 Feline JNK/MAPK9/JNK2 protein Feline
GM-Tg-cang-T69375-Ag-1/ GM-Tg-cang-T69375-Ag-2 Canine JNK/MAPK9/JNK2 protein Canine
GM-Tg-bovg-T69375-Ag-1/ GM-Tg-bovg-T69375-Ag-2 Bovine JNK/MAPK9/JNK2 protein Bovine
GM-Tg-equg-T69375-Ag-1/ GM-Tg-equg-T69375-Ag-2 Equine JNK/MAPK9/JNK2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T69375-Ag-1/ GM-Tg-hg-T69375-Ag-2; GM-Tg-rg-T69375-Ag-1/ GM-Tg-rg-T69375-Ag-2;
GM-Tg-mg-T69375-Ag-1/ GM-Tg-mg-T69375-Ag-2; GM-Tg-cynog-T69375-Ag-1/ GM-Tg-cynog-T69375-Ag-2;
GM-Tg-felg-T69375-Ag-1/ GM-Tg-felg-T69375-Ag-2; GM-Tg-cang-T69375-Ag-1/ GM-Tg-cang-T69375-Ag-2;
GM-Tg-bovg-T69375-Ag-1/ GM-Tg-bovg-T69375-Ag-2; GM-Tg-equg-T69375-Ag-1/ GM-Tg-equg-T69375-Ag-2
Products Name JNK/MAPK9/JNK2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name JNK/MAPK9/JNK2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JNK/MAPK9/JNK2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.