Explore FASLG/CD178 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
| Target ID |
GM-T64245
|
| Target Name |
FASLG/CD178
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
356
|
| Gene ID |
100052326 (Equus caballus), 14103 (Mus musculus), 25385 (Rattus norvegicus), 356 (Homo sapiens)
407111 (Bos taurus), 442968 (Canis lupus familiaris), 493945 (Felis catus), 574159 (Macaca mulatta)
|
| Target Alternative Names |
FASLG,Fasl,Faslg,fasL,TNLG1A,gld,CD178,CD95L,Fas-L,CD95-L,Tnfsf6,Tnlg1a,APT1LG1,Apt1Lg1,APTL,FASL,ALPS1B,TNFSF6
|
| Uniprot Accession |
P41047,P36940,P48023,Q861W5,P63307
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
cancer, Malignant neoplasm of bladder
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Alcoholic liver disease, Type I diabetes mellitus, Pathogenic Escherichia coli infection, Chagas disease, African trypanosomiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000016549, ENSMUSG00000000817, ENSG00000117560, ENSBTAG00000032808, ENSCAFG00845012259, ENSMMUG00000065134
|
| Target Classification |
|
Pre-made viral vector of FASLG/CD178 cDNA Clones/ORF Plasmid
FASLG/CD178 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo356 | Pre-made Human FASLG/APTL/FASL siRNA oligo Duplex | 356 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25385 | Pre-made Rat Faslg/Fasl/CD95-L siRNA oligo Duplex | 25385 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14103 | Pre-made Mouse Fasl/gld/CD178 siRNA oligo Duplex | 14103 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574159 | Pre-made Cynomolgus/Rhesus macaque FASLG/FASL/CD95L siRNA oligo Duplex | 574159 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493945 | Pre-made Cat/Feline FASLG/FASL/TNFSF6 siRNA oligo Duplex | 493945 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442968 | Pre-made Dog/Canine FASLG/FASL/TNLG1A siRNA oligo Duplex | 442968 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407111 | Pre-made Bovines/Cattle FASLG siRNA oligo Duplex | 407111 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052326 | Pre-made Equine/Horse FASLG/fasL/TNLG1A siRNA oligo Duplex | 100052326 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FASLG/CD178 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T64245-Ab | Human | Anti-Human FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T64245-Ab | Rat | Anti-Rat FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T64245-Ab | Mouse | Anti-Mouse FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T64245-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T64245-Ab | Cat/Feline | Anti-Cat/Feline FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T64245-Ab | Dog/Canine | Anti-Dog/Canine FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T64245-Ab | Bovines/Cattle | Anti-Bovines/Cattle FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T64245-Ab | Equine/Horse | Anti-Equine/Horse FASLG/CD178 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
FASLG/CD178 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T64245-Ag | Human | Human FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T64245-Ag | Rat | Rat FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T64245-Ag | Mouse | Mouse FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T64245-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T64245-Ag | Cat/Feline | Cat/Feline FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T64245-Ag | Dog/Canine | Dog/Canine FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T64245-Ag | Bovines/Cattle | Bovines/Cattle FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T64245-Ag | Equine/Horse | Equine/Horse FASLG/CD178 VLP (virus-like particle) | HEK293 | Products Developing |
